Mechanisms of recovery from aphasia: evidence from serial xenon 133 cerebral blood flow studies.
Mechanisms of recovery from aphasia: evidence from serial xenon 133 cerebral blood flow studies.
复制标题
失语症恢复机制：来自连续氙 133 脑血流研究的证据。
DOI：
10.1002/ana.410150604
复制
发表时间：
1984
影响因子：
11.2
通讯作者：
Meyer,MW
中科院分区：
文献类型：
--
作者：
Knopman,DS;Rubens,AB;Selnes,OA;Klassen,AC;Meyer,MW
对21例左半球缺血性脑梗死失语患者，采用氙133吸入脑血流技术，分别于脑卒中后3个月和5 ~ 12个月测定脑血流。除了基线测量外，还在患者进行有目的的听力时进行了脑血流量测量。在理解力恢复不完全和左后颞下顶叶病变的患者中，在后期研究中右下额叶区域的听力比早期研究中出现更大的脑血流量。在理解力几乎完全恢复且无左后颞下顶叶病变的患者中，早期听力检查显示右半球脑血流量弥漫性增加。在后一组患者中，后来的听力研究显示左后颞下顶叶区域的脑血流量更大。这项研究提供了证据，证明右半球参与了失语症患者的语言理解恢复，以及在恢复早期可能功能受损的左半球区域的功能恢复。
In 21 patients who suffered aphasia resulting from left hemisphere ischemic infarction, the xenon 133 inhalation cerebral blood flow techique was used to measure cerebral blood flow within 3 months and 5 to 12 months after stroke. In addition to baseline measurements, cerebral blood flow measurements were also carried out while the patients were performing purposeful listening. In patients with incomplete recovery of comprehension and left posterior temporal–inferior parietal lesions, greater cerebral blood flow occurred with listening in the right inferior frontal region in the late studies than in the early studies. In patients with nearly complete recovery of comprehension and without left posterior temporal–inferior parietal lesions, early listening studies showed diffuse right hemisphere increases in cerebral blood flow. Later listening studies in this latter patient group showed greater cerebral blood flow in the left posterior temporal–inferior parietal region. The study provides evidence for participation of the right hemisphere is language comprehension in recovering aphasics, and for later return of function in left hemisphere regions that may have been functionally impaired early during recovery.