Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice
Effect of hesperidin on neurobehavioral, neuroinflammation, oxidative stress and lipid alteration in intracerebroventricular streptozotocin induced cognitive impairment in mice
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DOI：
10.1016/j.jns.2014.10.044
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发表时间：
2015-01-15
影响因子：
4.4
通讯作者：
Islam, Fakhrul
中科院分区：
文献类型：
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作者：
Javed, Hayate;Vaibhav, Kumar;Islam, Fakhrul
最近的注意力被给予对健康和心理健康的饮食补充的影响。氧化应激与许多疾病有关，包括神经退行性疾病。膳食类黄酮发挥化学预防和神经保护作用，并包括最常见的植物多酚，提供了蔬菜和水果的味道和颜色。橙皮苷是柑橘类水果中大量存在的一种黄酮苷，具有抗氧化、降血脂、镇痛和抗高血压等作用。对瑞士雄性白化病小鼠进行橙皮苷预处理（100和200 mg/kg体重，每日一次，持续15天）可预防认知障碍。通过单次侧脑室注射链脲佐菌素（ICV-STZ）（每侧2.57 mg/kg体重）建立认知障碍。橙皮苷预处理可改善记忆巩固过程，其机制可能与调节乙酰胆碱酯酶活性有关。此外，橙皮苷衰减减少还原型谷胱甘肽（GSH）的含量和硫代巴比妥酸反应物质（TBARS）的水平升高，也增加了ICV-STZ注射后的脂质变化显着。我们还证明类黄酮橙皮苷通过抑制炎症标志物如核因子κ B、诱导型一氧化氮合酶、环氧合酶-2和胶质细胞酸性蛋白阳性星形胶质细胞的过表达来调节神经元细胞死亡。本研究的结果打开了使用黄酮类化合物作为散发性阿尔茨海默病痴呆症潜在新治疗策略的可能性。(C)© 2014 Elsevier B. V.保留所有权利。
Recent attention is given to the influence of dietary supplementation on health and mental well-being. Oxidative stress is associated with many diseases including neurodegenerative disorders. Dietary flavonoids exert chemopreventive and neuroprotective effects and comprise the most common group of plant polyphenols that provide much of the flavour and colour of the vegetables and fruits. Hesperidin is a flavanone glycoside found abundantly in citrus fruits, has been reported to have antioxidant, hypolipidaemic, analgesic and antihypertensive activity. Pretreatment of hesperidin (100 and 200 mg/kg body weight orally once daily for 15 days) to Swiss male albino mice has prevented the cognitive impairment. The cognitive impairment was developed by giving single intracerebroventricular-streptozotocin (ICV-STZ) injection (2.57 mg/kg body weight each side) bilaterally. Hesperidin pretreatment improved memory consolidation process as tested by Morris water maze possibly through modulation of acetylcholine esterase activity (AChE). Moreover, hesperidin attenuated the depleted content of reduced glutathione (GSH) and elevated level of thiobarbituric acid reactive substances (TBARS) and also augmented lipid alteration significantly following ICV-STZ injection. We also demonstrated that the flavonoid hesperidin modulates neuronal cell death by inhibiting the overexpression of inflammatory markers like nuclear factor kappa B, inducible nitric oxide synthase, cyclooxygenase-2 and glial fibrillary acidic protein positive astrocytes. The results from the present study open the possibility of using flavonoids for potential new therapeutic strategies for sporadic dementia of Alzheimer's disease. (C) 2014 Elsevier B.V. All rights reserved.