Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep
Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep
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DOI：
10.1016/s0896-6273(01)00186-6
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发表时间：
2001-01-01
期刊：
影响因子：
16.2
通讯作者：
Wilson, MA
中科院分区：
文献类型：
--
作者：
Louie, K;Wilson, MA
人类做梦发生在快速眼动 (REM) 睡眠期间。为了研究快速眼动睡眠期间的神经活动结构，我们同时记录了大鼠海马体在睡眠和清醒行为期间多个神经元的活动。我们表明，在 REM 发作期间，以相同的时间尺度再现了反映数十秒到几分钟行为体验的时间序列整体放电率模式。此外，在这种快速眼动发作中，皮层下驱动的θ节律的行为依赖性调节也被再现。这些结果表明，暗示情景记忆痕迹的模式化多神经元活动的长时间序列在快速眼动睡眠期间被重新激活。这种重新激活可能对记忆处理很重要，并为梦状态内容的电生理检查提供基础。
Human dreaming occurs during rapid eye movement (REM) sleep. To investigate the structure of neural activity during REM sleep, we simultaneously recorded the activity of multiple neurons in the rat hippocampus during both sleep and awake behavior. We show that temporally sequenced ensemble firing rate patterns reflecting tens of seconds to minutes of behavioral experience are reproduced during REM episodes at an equivalent timescale. Furthermore, within such REM episodes behavior-dependent modulation of the subcortically driven theta rhythm is also reproduced. These results demonstrate that long temporal sequences of patterned multineuronal activity suggestive of episodic memory traces are reactivated during REM sleep. Such reactivation may be important for memory processing and provides a basis for the electrophysiological examination of the content of dream states.