How do short-term changes at synapses fine-tune information processing?
How do short-term changes at synapses fine-tune information processing?
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DOI：
10.1523/jneurosci.3348-12.2012
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发表时间：
2012-10-10
期刊：
影响因子：
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通讯作者：
Xu-Friedman MA
中科院分区：
文献类型：
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作者：
Klug A;Borst JG;Carlson BA;Kopp-Scheinpflug C;Klyachko VA;Xu-Friedman MA
突触传递高度依赖于最近的活动，并可导致抑制或促进突触强度。这种现象被称为“短时突触可塑性”(STP)，在所有突触都有表现。虽然已经做了很多工作来了解突触状态短期变化的机制，但短期可塑性通常被认为是突触设计的机械结果。这篇综述将试图超越这一观点，一方面讨论复杂的神经元活动如何影响突触的短期状态，另一方面也讨论这些突触强度的动态变化如何反过来影响信息处理。
Synaptic transmission is highly dependent on recent activity, and can lead to depression or facilitation of synaptic strength. This phenomenon is called “short-term synaptic plasticity” (STP) and is shown at all synapses. While much work has been done to understand the mechanisms of short-term changes in the state of synapses, short-term plasticity is often thought of as a mechanistic consequence of the design of a synapse. This review will attempt to go beyond this view and discuss how, on one hand, complex neuronal activity affects the short-term state of synapses, but also how these dynamic changes in synaptic strength affects information processing in return.