Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer
Clinical significance of immunohistochemical expression of insulin-like growth factor-1 receptor and matrix metalloproteinase-7 in resected non-small cell lung cancer
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DOI：
10.3892/etm.2012.493
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发表时间：
2012-05-01
影响因子：
2.7
通讯作者：
Imada, Toshio
中科院分区：
文献类型：
--
作者：
Yamamoto, Taketsugu;Oshima, Takashi;Imada, Toshio
据报道，胰岛素样生长因子1受体（IGF-IR）和基质金属蛋白酶7（MMP-7）与多种恶性肿瘤的肿瘤侵袭和转移有关。本研究的目的是评估切除的非小细胞肺癌（NSCLC）中IGF-1R和MMP-7的表达水平，并检查这些水平与临床特征和生存的关系。通过免疫组织化学方法测量表达。染色细胞的百分比乘以染色强度。当分数等于或高于中值时，样本被分类为高，否则被视为低。 IGF-1R 高表达与淋巴结转移和复发相关（P 分别为 0.034 和 0.006）。高 IGF-IR 表达与低 IGF-IR 表达相比，总体生存率显着较差 (P=0.011)。 MMP-7 表达与任何临床病理因素均无显着相关性。 MMP-7 高肿瘤患者的生存率比 MMP-7 低肿瘤患者的生存率有轻微但不显着较差的趋势 (P=0.220)。 IGF-IR表达与MMP-7表达无显着相关性(P=0.184)。经过多变量分析，IGF-IR 表达与 NSCLC 患者的预后独立相关。 IGF-IR 的过表达可能是 NSCLC 患者淋巴结转移、复发和术后结果的有用预测因子。
Insulin-like growth factor-1 receptor (IGF-IR) and matrix metalloproteinase-7 (MMP-7) have been reported to be related to tumor invasion and metastasis in various malignancies. The aim of this study was to evaluate the expression levels of IGF-1R and MMP-7 in resected non-small cell lung cancer (NSCLC) and to examine the relationship of such levels to clinical characteristics and survival. Expression was measured immunohistochemically. The percentage of stained cells was multiplied by the staining intensity. The sample was classified as high when the score was equal or higher than the median value or was otherwise considered to be low. High IGF-1R expression was associated with nodal metastasis and recurrence (P=0.034 and 0.006, respectively). High IGF-IR expression was associated with significantly poorer overall survival than low IGF-IR expression (P=0.011). MMP-7 expression did not significantly correlate with any clinicopathological factor. There was a trend toward slightly, but not significantly poorer survival in patients with MMP-7-high tumors than in those with MMP-7-low tumors (P=0.220). There was no significant correlation between IGF-IR expression and MMP-7 expression (P=0.184). Upon multivariate analysis, IGF-IR expression was independently related to the outcomes of patients with NSCLC. Overexpression of IGF-IR may be a useful predictor of lymph node metastasis, recurrence and post-surgical outcomes in patients with NSCLC.