Rapid access to conformational analogues of (+)-peloruside A.
Rapid access to conformational analogues of (+)-peloruside A.
复制标题
快速获得 ( )-peloruside A 的构象类似物。
DOI：
10.1021/ol203268t
复制
发表时间：
2012
期刊：
影响因子：
5.2
通讯作者：
Taylor,RichardE
中科院分区：
文献类型：
--
作者：
Zhao,Zhiming;Taylor,RichardE
已经证明了一种快速获得peloruside A类似物的有效合成策略。通过简单的基于缩合的片段偶联和后期闭环复分解反应突出了合成路线。这种收敛的路线提供了合理设计的类似物的灵感来自于溶液构象偏好的peloruside A。
An efficient synthetic strategy for rapid access to analogues of peloruside A has been demonstrated. The synthetic route was highlighted by a simple esterification-based fragment coupling and a late stage ring-closing metathesis reaction. This convergent route has provided access to rationally designed analogues inspired by the solution conformational preferences of peloruside A.