WSKY, a traditional Chinese decoction, rescues cognitive impairment associated with NMDA receptor antagonism by enhancing BDNF/ERK/CREB signaling
WSKY, a traditional Chinese decoction, rescues cognitive impairment associated with NMDA receptor antagonism by enhancing BDNF/ERK/CREB signaling
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DOI：
10.3892/mmr.2014.3086
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发表时间：
2015-04-01
影响因子：
3.4
通讯作者：
Wang, Gao-Hua
中科院分区：
文献类型：
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作者：
Guo, Xin;Chen, Zheng-Hua;Wang, Gao-Hua
温补肾阳（WSKY）是一种草药处方，已在传统中医中用于治疗精神疾病。我们小组以前的一项研究发现，WSKY显着改善精神分裂症患者的认知功能。本研究探讨了WSKY对认知功能的影响及其机制。将WSKY给予MK-801诱导的慢性精神分裂症大鼠模型14天。使用Morris水迷宫（MWM）测试评估记忆性能。Western blot检测海马区脑源性神经营养因子（BDNF）的表达、cAMP反应元件结合蛋白（pCREB/CREB）的活化和细胞外信号调节激酶（pERK/ERK）的活化。与正常对照组相比，MK-801组大鼠在获得期的逃避潜伏期明显延长（P
Warm-supplementing kidney yang (WSKY) is an herbal prescription that has been used in Traditional Chinese Medicine for the treatment of psychiatric conditions. A previous study by our group found that WSKY significantly improved cognitive function of schizophrenia patients. In the present study, the effects of WSKY on cognitive function and their underlying mechanisms were investigated. WSKY was administered to an MK-801-induced rat model of chronic schizophrenia for 14 days. Memory performance was assessed using the Morris water maze (MWM) test. The expression of brain-derived neurotrophic factor (BDNF), activation of cAMP response element binding protein (pCREB/CREB) and activation of extracellular signal-regulated kinase (pERK/ERK) in the hippocampus was detected using western blot analysis. In the acquisition phase of the MWM test, the escape latency was significantly increased in the MK-801-treated group compared with the normal control group (P