Impairment of decision making associated with disruption of phase-locking in the anterior cingulate cortex in viscerally hypersensitive rats
Impairment of decision making associated with disruption of phase-locking in the anterior cingulate cortex in viscerally hypersensitive rats
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DOI：
10.1016/j.expneurol.2016.09.010
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发表时间：
2016-12-01
影响因子：
5.3
通讯作者：
Li, Ying
中科院分区：
文献类型：
--
作者：
Cao, Bing;Wang, Jun;Li, Ying
内脏超敏反应（VH）是肠易激综合征（IBS）的一个关键因素。先前的研究已经确定了前扣带皮层（ACC）对VH大鼠结肠直肠扩张的增强反应，这可以在结肠过敏反应后长达7周观察到，与结肠炎症无关。VH的诱导。在ACC回路中引起随后的突触可塑性的能力发生变化。在临床实践中，IBS和认知障碍之间的积极联系已经被注意到多年，但没有动物模型的报道。决策是监测动物高阶认知功能的一个有价值的模型，它依赖于ACC和杏仁核几个子区域的综合功能。本研究采用大鼠赌博任务（RGT），观察了VH大鼠的决策行为障碍。电生理研究显示VH大鼠基底外侧杏仁核（BLA）-ACC突触的长时程增强减少。多电极阵列记录局部场电位（LFP）在BLA和ACC也进行了自由行为的大鼠。尖峰场相干性（SFC）分析显示，慢性内脏痛导致ACC尖峰时序和BLA局部θ振荡中断。最后，交叉相关分析显示，VH与抑制BLA和ACC之间的θ振荡的同步，这表明在VH状态下这两个区域之间的神经元通信减少。本研究结果表明，在BLA-ACC神经回路的功能障碍可能是在慢性疼痛状态下的决策缺陷的相关原因。(C)2016由Elsevier Inc.出版
Visceral hypersensitivity (VH) is a key factor of irritable bowel syndrome (IBS). Previous studies have identified an enhanced response of anterior cingulate cortex (ACC) to colorectal distension in VH rats, which can be observed up to 7 weeks following colonic anaphylaxis, independent of colonic inflammation. The induction of VH. produces a change in the ability to induce subsequent synaptic plasticity at the ACC circuitry. In clinical practice, a positive link between IBS and cognitive impairments has been noted for years, but no animal model has been reported. Decision-making is a valuable model for monitoring higher-order cognitive functions in animals, which depends on the integrated function of several sub-regions of the ACC and amygdala. Using rat gambling task (RGT) in the present study, we observed an impairment of decision-making behavior in VH rats. Electro-physiological study showed a reduction of long-term potentiation in the basolateral amygdala (BLA)-ACC synapses in VH rats. Multiple-electrode array recordings of local field potential (LFP) in both BLA and ACC were also performed in freely behaving rats. Spike-field coherence (SFC) analysis revealed chronic visceral pain led to disruption of ACC spike timing and BLA local theta oscillation. Finally, cross-correlation analysis revealed that VH was associated with suppressed synchronization of theta oscillation between the BLA and ACC, indicating reduced neuronal communications between these two regions under the VH state. The present results demonstrate that functional disturbances in BLA-ACC neural circuitry may be relevant causes for the deficits in decision-making in chronic pain state. (C) 2016 Published by Elsevier Inc.