FUNCTIONAL SIMILARITIES OF HEPATIC CYSTIC AND BILIARY EPITHELIUM - STUDIES OF FLUID CONSTITUENTS AND INVIVO SECRETION IN RESPONSE TO SECRETIN
FUNCTIONAL SIMILARITIES OF HEPATIC CYSTIC AND BILIARY EPITHELIUM - STUDIES OF FLUID CONSTITUENTS AND INVIVO SECRETION IN RESPONSE TO SECRETIN
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DOI：
10.1002/hep.1840110406
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发表时间：
1990-04-01
期刊：
影响因子：
13.5
通讯作者：
THICKMAN, D
中科院分区：
文献类型：
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作者：
EVERSON, GT;EMMETT, M;THICKMAN, D
肝囊肿是常染色体显性遗传性多囊肾病的常见表现，但对其功能特征知之甚少。本研究的目的是确定肝囊肿液的成分，并确定肝囊肿是否对静脉注射促胰液素产生反应。我们对6名患有常染色体显性多囊肾病的受试者的5个肝囊肿和1个近端肾囊肿以及1名没有常染色体显性多囊肾病的受试者的1个孤立性肝囊肿进行了穿刺。大多数液体的电解质组成与血清相似。所有肝囊肿液中谷氨酰转肽酶浓度均高于血清（[囊肿]/[血清] = 4.93 . ±. 5.92），含有分泌成分（聚合伊加的上皮受体），并且具有小于15 mg/dl的葡萄糖浓度。常染色体显性遗传性多囊肾病受试者的肝和肾囊肿的液体，但不是来自孤立性肝囊肿的受试者，表现出几种血清蛋白电泳迁移率的广泛变化。最初的囊内压力范围为16至40厘米水柱，减少57%至97%后，抽吸的一部分囊液，并保持恒定的分泌研究。在8分钟内的静脉注射促胰液素，分泌的液体增加，在两个三个肝囊肿和肾囊肿。囊液的电解质组成没有被促胰液素改变。这些数据表明，肝囊性上皮细胞具有胆管上皮细胞的功能特征，肝和肾囊肿的分泌可能受到尿道调节。
Hepatic cysts are a frequent manifestation of autosomal dominant polycystic kidney disease, but little is known about their functional characteristics. The goals of our study were to define the composition of hepatic cyst fluid and to determine whether hepatic cysts secrete in response to intravenously administered secretin. We percutaneously punctured five hepatic cysts and one proximal renal cyst from six subjects with autosomal dominant polycystic kidney disease and one solitary hepatic cyst from a subject without autosomal dominant polycystic kidney disease. Most fluids had an electrolyte composition similar to serum. Fluid from all hepatic cysts had glutamyltranspeptidase concentrations above those found in serum ([cyst]/[serum] = 4.93 .+-. 5.92), contained secretory component (the epithelial receptor for polymeric IgA) and had glucose concentrations less than 15 mg/dl. Fluid from both hepatic and renal cysts of subjects with autosomal dominant polycystic kidney disease, but not from the subject with the solitary hepatic cyst, demonstrated extensive changes in the electrophoretic mobility of several serum proteins. Initial intracystic pressures ranged from 16 to 40 cm H2O, were reduced 57% to 97% after aspiration of a portion of cyst fluid and were held constant during the secretion study. Within 8 min of the intravenous administration of secretin, secretion of fluid increased in two of three hepatic cysts and in the renal cyst. The electrolyte composition of cyst fluids was not altered by secretin. These data suggest that hepatic cystic epithelium has functional characteristics of biliary epithelium and that secretion by both hepatic and renal cysts may be hormonally regulated.