LEUKEMIA AMONG CHILDREN IN A SUBURBAN COMMUNITY
LEUKEMIA AMONG CHILDREN IN A SUBURBAN COMMUNITY
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DOI：
10.1016/0002-9343(63)90088-3
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发表时间：
1963-01-01
影响因子：
5.9
通讯作者：
HASTERLIK, RJ
中科院分区：
文献类型：
--
作者：
HEATH, CW;HASTERLIK, RJ
在1957年至1960年间，伊利诺斯州奈尔斯的一个居民区发生了8例白血病。这8个孩子中有7个来自罗马天主教家庭，这7个孩子中的每一个都参加了社区的一所教区小学，或者有哥哥姐姐参加了社区的一所教区小学。这些病例构成了该镇儿童贫血发病率的显著增加，它们与一所学校的联系超出了偶然的预期。这8例病例发生在两个不同的时间段内，并伴有同一教区学校学生中的“类风湿”疾病。在同一社区内，发现成人白血病和儿童白血病以外的癌症病例仅限于罗马天主教家庭，其中4人居住在一个街区内。观察到与先天性心脏病有关的不寻常的儿童死亡率，其中病例也仅限于罗马天主教家庭。教区学校的巩固和社区人口的迅速扩张可能是这种不寻常的白血病发生的原因。虽然这些病例的确切原因尚未查明，但它们与一所特定学校的联系、发生的时间模式以及“类风湿”疾病的平行出现表明它们与感染有病原学关系。
Between 1957 and 1960 eight cases of leukemia occurred among children living in one residential area of Niles, Illinois. Seven of these 8 children were from Roman Catholic families, and each of these 7 either attended or had older siblings who attended the community''s one parochial elementary school. These cases constituted a significantly increased incidence of luekemia in children for this town, and their association with a single school exceeded chance expectation. The 8 cases occurred within 2 separate periods of time, and were accompanied by a "rheumatic-like" illness among pupils in the same parochial school. Within this same community, cases of leukemia in adults and of cancers other than leukemia in children were found limited to Roman Catholic families, 4 of whom lived within a single block area. An unusual childhood mortality associated with congenital heart disease was observed in which cases were also limited to Roman Catholic families. Consolidation in the parochial school and rapid population expansion in the community may have been contributing factors in this unusual occurrence of leukemia. Although the exact cause of these cases was not identified, their association with one particular school, the time pattern of their occurrence and the parallel appearance of a "rheumatic-like" illness suggest an etiologic relationship to infection.