Intra-individual reaction time variability and all-cause mortality over 17 years: a community-based cohort study
Intra-individual reaction time variability and all-cause mortality over 17 years: a community-based cohort study
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DOI：
10.1093/ageing/aft116
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发表时间：
2014-01-01
期刊：
影响因子：
6.7
通讯作者：
Christensen, Helen
中科院分区：
文献类型：
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作者：
Batterham, Philip J.;Bunce, David;Christensen, Helen
背景：很少有研究探讨个体内反应时间变异性与随后死亡率之间的关系。此外，简单的变异性的措施，以预测mortality的能力还没有比较与更复杂的measures.Method：一个前瞻性队列研究896社区为基础的澳大利亚成年人70岁以上的人进行了采访，从1990年至2002年，直到2007年6月的生命状态评估。从这个队列中，770-790名参与者被纳入生存的考克斯比例风险回归模型。使用生命状态和研究时间进行生存分析。在20个简单和选择反应时间任务的试验中，分别计算平均反应时间和个体内反应时间变异性的三个指标。模型进行了调整的一系列人口，身体健康和心理健康的measures.Results：更大的个体内简单反应时间的变异性，评估的原始标准差（原始SD），变异系数（CV）或个体内标准差（ISD），是密切相关的风险增加的全因死亡率在调整后的考克斯回归模型。平均反应时间没有显着的关联与mortality.Conclusion：在简单的反应时间的个体内变异似乎有一个强大的关联超过17年的死亡率。健康专业人员，如神经心理学家，可以通过测试简单的反应时间和计算原始SD或CV的简单过程来补充神经精神测试，从而在神经病理学的检测中受益。
Background: very few studies have examined the association between intra-individual reaction time variability and subsequent mortality. Furthermore, the ability of simple measures of variability to predict mortality has not been compared with more complex measures.Method: a prospective cohort study of 896 community-based Australian adults aged 70+ were interviewed up to four times from 1990 to 2002, with vital status assessed until June 2007. From this cohort, 770-790 participants were included in Cox proportional hazards regression models of survival. Vital status and time in study were used to conduct survival analyses. The mean reaction time and three measures of intra-individual reaction time variability were calculated separately across 20 trials of simple and choice reaction time tasks. Models were adjusted for a range of demographic, physical health and mental health measures.Results: greater intra-individual simple reaction time variability, as assessed by the raw standard deviation (raw SD), coefficient of variation (CV) or the intra-individual standard deviation (ISD), was strongly associated with an increased hazard of all-cause mortality in adjusted Cox regression models. The mean reaction time had no significant association with mortality.Conclusion: intra-individual variability in simple reaction time appears to have a robust association with mortality over 17 years. Health professionals such as neuropsychologists may benefit in their detection of neuropathology by supplementing neuropsychiatric testing with the straightforward process of testing simple reaction time and calculating raw SD or CV.