Prediction of tricyclic antidepressant response: a critical review.
Prediction of tricyclic antidepressant response: a critical review.
复制标题
三环类抗抑郁药反应的预测：批判性回顾。
DOI：
10.1001/archpsyc.1976.01770120083009
复制
发表时间：
1976
影响因子：
--
通讯作者：
R. O. Friedel
中科院分区：
文献类型：
--
作者：
R. Bielski;R. O. Friedel
本文综述了所有前瞻性、双盲对照研究，评价了盐酸丙咪嗪和盐酸阿米替林对抑郁症患者的反应预测。尽管有广泛不同的方法，试图从这些数据中提取临床有用的结论。每项研究的批评和在他们的评估中使用的标准，包括未来的研究建议。对丙咪嗪和阿米替林有阳性反应的预测因素为：社会经济地位较高、起病隐匿、厌食、体重减轻、中晚期失眠和精神障碍。反应不良的预测因素如下：神经质、低智性和歇斯底里特征、多次既往发作和妄想。治疗前尿3-甲氧基-4-羟基苯乙二醇（MHPG）水平可能有一天是有用的，在预测这两个三环类抗抑郁药的患者将响应。
This article reviews all the prospective, double-blind controlled studies that have evaluated the prediction of response to imipramine hydrochloride and amitriptyline hydrochloride in depressed patients. Despite widely divergent methodologies, an attempt is made to extract clinically useful conclusions from these data. Critiques of each study and the criteria used in their evaluation are presented, with suggestions for future research included. The predictors of positive response to imipramine and amitriptyline are as follows: upper socioeconomic class, insidious onset, anorexia, weight loss, middle and late insomnia, and psychomotor disturbance. The predictors of poor response are the following: neurotic, hypochondriacal, and hysterical traits, multiple prior episodes, and delusions. Pretreatment urinary 3-methoxy-4-hydroxyphenylglycol (MHPG) levels may some day be useful in predicting to which of these two tricyclic antidepressants a patient will respond.