Association of schizophrenia and autoimmune diseases: Linkage of Danish National Registers
Association of schizophrenia and autoimmune diseases: Linkage of Danish National Registers
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DOI：
10.1176/appi.ajp.163.3.521
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发表时间：
2006-03-01
影响因子：
17.7
通讯作者：
Mortensen, PB
中科院分区：
文献类型：
--
作者：
Eaton, WW;Byrne, M;Mortensen, PB
目的：精神分裂症患者及其亲属的自身免疫性疾病患病率往往高于或低于预期，尤其是类风湿性关节炎、乳糜泻、自身免疫性甲状腺疾病和 1 型糖尿病。该研究的目的是在一项大型流行病学研究中评估精神分裂症与这些疾病以及一系列其他自身免疫性疾病的关联。方法：将丹麦精神病学登记册、国家患者登记册和社会经济信息登记册连接起来，形成一个数据文件，其中包括 1981 年至 1998 年丹麦所有 7,704 名被诊断患有精神分裂症的人及其父母以及匹配比较样本受试者及其父母。数据关联要求自身免疫性疾病发生在精神分裂症诊断之前。结果：任何自身免疫性疾病病史与精神分裂症风险增加 45% 相关。精神分裂症患者中 9 种自身免疫性疾病的患病率高于对照组（粗发病率比为 1.9 至 12.5），精神分裂症患者父母中 12 种自身免疫性疾病的患病率高于对照组（调整后发病率比为 1.3 至 3.8）。精神分裂症患者中甲状腺毒症、乳糜泻、获得性溶血性贫血、间质性膀胱炎和干燥综合征的患病率高于对照组，精神分裂症患者家庭成员的患病率也高于对照组家庭成员。结论：精神分裂症与自身免疫性疾病的范围比迄今为止所怀疑的要大。未来对共病的研究有可能促进对精神疾病和自身免疫性疾病发病机制的理解。
Objective: Individuals with schizophrenia and their relatives tend to have either higher or lower than expected prevalences of autoimmune disorders, especially rheumatoid arthritis, celiac disease, autoimmune thyroid diseases, and type 1 diabetes. The purpose of the study was to estimate the association of schizophrenia with these disorders as well as a range of other autoimmune diseases in a single large epidemiologic study.Method: The Danish Psychiatric Register, the National Patient Register, and a register with socioeconomic information were linked to form a data file that included all 7,704 persons in Denmark diagnosed with schizophrenia from 1981 to 1998 and their parents along with a sample of matched comparison subjects and their parents. The data linkage required that the autoimmune disease occur before the diagnosis of schizophrenia.Results: A history of any autoimmune disease was associated with a 45% increase in risk for schizophrenia. Nine autoimmune disorders had higher prevalence rates among patients with schizophrenia than among comparison subjects (crude incidence rate ratios ranging from 1.9 to 12.5), and 12 autoimmune diseases had higher prevalence rates among parents of schizophrenia patients than among parents of comparison subjects (adjusted incidence rate ratios ranging from 1.3 to 3.8). Thyrotoxicosis, celiac disease, acquired hemolytic anemia, interstitial cystitis, and Sjogren's syndrome had higher prevalence rates among patients with schizophrenia than among comparison subjects and also among family members of schizophrenia patients than among family members of comparison subjects.Conclusions: Schizophrenia is associated with a larger range of autoimmune diseases than heretofore suspected. Future research on comorbidity has the potential to advance understanding of pathogenesis of both psychiatric and autoimmune disorders.