Innate immune response and bronchiolitis and preschool recurrent wheeze
Innate immune response and bronchiolitis and preschool recurrent wheeze
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DOI：
10.1016/j.prrv.2008.05.005
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发表时间：
2008-12-01
影响因子：
5.8
通讯作者：
Smyth, Rosalind L.
中科院分区：
文献类型：
--
作者：
Halfhide, Clare;Smyth, Rosalind L.
毛细支气管炎和学龄前反复喘息(PSRW)是儿科常见的问题，在出生后的第一年会导致显著的发病率和死亡率，呼吸道合胞病毒(RSV)和鼻病毒是与这些疾病相关的最常见的病原体，因此一些婴儿受到严重影响，需要住院治疗。其他人患了简单的感冒还没有完全了解：研究表明，对这些病毒的先天免疫反应很重要。先天免疫系统有许多组成部分，一个或多个区域的激活或不足可能解释了这些婴儿可能出现的不同临床表现和疾病严重程度。这篇综述将总结最近的证据，强调RSV和鼻病毒如何调节毛细支气管炎和PSRW的先天免疫反应，并讨论这些疾病如何影响婴儿肺的长期发育以及对持续性呼吸道疾病的可能易感性。(C)2008爱思唯尔有限公司。保留所有权利。
Bronchiolitis and preschool recurrent wheeze (PSRW) are common paediatric problems causing significant morbidity and mortality in the first years of life, Respiratory syncytial virus (RSV) and rhinoviruses are the commonest pathogens associated with these illnesses, Why some infants are severely affected, requiring admission to hospital. whist others experience a simple cold is not fully understood: research has suggested that the innate immune response to these viruses is important. The innate immune system has many components and activation or deficiency in one or many areas may explain the different clinical presentations and disease severities that can occur in these infants. This review will summarize the recent evidence highlighting how RSV and rhinoviruses may modulate the innate immune response in both bronchiolitis and PSRW, and discuss how these illnesses affect the long-term development of the infant lung and the possible susceptibility to persistent airway disease. (C) 2008 Elsevier Ltd. All rights reserved.