Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells.
Follicular regulatory T cells can be specific for the immunizing antigen and derive from naive T cells.
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DOI：
10.1038/ncomms10579
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发表时间：
2016-01-28
影响因子：
16.6
通讯作者：
Linterman MA
中科院分区：
文献类型：
--
作者：
Aloulou M;Carr EJ;Gador M;Bignon A;Liblau RS;Fazilleau N;Linterman MA
滤泡调节性T（Tfr）细胞是响应于免疫或感染而形成的Foxp 3+调节性T（Treg）细胞的子集，其定位于生发中心，在那里它们控制响应的大小。尽管人们对Tfr细胞在体液免疫中的作用越来越感兴趣，但其生物学的许多基本方面仍然未知，包括它们是否识别自身抗原或外源抗原。在这里，我们表明，Tfr细胞可以是特异性的免疫抗原，无论它是一个自我或外来抗原。我们发现，除了从胸腺来源的Treg细胞发育之外，如果使用的佐剂是支持T细胞可塑性的佐剂，Tfr细胞也可以以PD-L1依赖的方式从Foxp 3 −前体中产生。这些发现对Tfr细胞生物学和通过配制改变Tfr：Tfh细胞比率的疫苗来提高疫苗效力具有重要意义。滤泡调节性T细胞控制生发中心反应的大小。在这里，作者表明，这些细胞对自身和外源抗原具有特异性，并且可以在免疫的早期阶段以PD-L1依赖性方式从Foxp 3阴性前体产生。
T follicular regulatory (Tfr) cells are a subset of Foxp3+ regulatory T (Treg) cells that form in response to immunization or infection, which localize to the germinal centre where they control the magnitude of the response. Despite an increased interest in the role of Tfr cells in humoral immunity, many fundamental aspects of their biology remain unknown, including whether they recognize self- or foreign antigen. Here we show that Tfr cells can be specific for the immunizing antigen, irrespective of whether it is a self- or foreign antigen. We show that, in addition to developing from thymic derived Treg cells, Tfr cells can also arise from Foxp3− precursors in a PD-L1-dependent manner, if the adjuvant used is one that supports T-cell plasticity. These findings have important implications for Tfr cell biology and for improving vaccine efficacy by formulating vaccines that modify the Tfr:Tfh cell ratio. T follicular regulatory cells control the magnitude of the germinal centre response. Here the authors show that these cells display specificity to self as well as foreign antigens, and can arise from Foxp3-negative precursors at early stages of immunization in a PD-L1 dependent manner.