A twin study of the genetic contribution to age-related functional impairment.
A twin study of the genetic contribution to age-related functional impairment.
复制标题
关于遗传对年龄相关功能障碍的影响的双胞胎研究。
DOI：
10.1093/gerona/59.8.m859
复制
发表时间：
2004
期刊：
影响因子：
--
通讯作者：
Plassman,BrendaL
中科院分区：
文献类型：
--
作者：
Gurland,BarryJ;Page,WilliamF;Plassman,BrendaL
背景：老年人晚年生活质量的一个关键因素是与年龄相关的功能障碍的流行。本研究的目的是量化遗传和环境对白色男性双胞胎老年人年龄相关的功能障碍的影响，这些老年人在进入军队服役时适合年轻的成年人。遗传对功能在以后的生活中的影响程度的作用，公共卫生，个人的主动性，和服务interventions.Methods。功能障碍的指标，通过电话调查和双胞胎对10个指标的基本，工具和社会活动，和流动性的反应。使用结构方程模型分析响应。患病率和一致性由合子状态决定。协方差被分配到一对双胞胎之间的组件归因于添加剂遗传学，共同的环境，和独特的environment.Results.Data从2721双胞胎对（1384单卵和1337双卵）进行了分析的10个二分指标的功能障碍和子量表的8个这些指标。对于分量表，加性基因约占21%的协方差，而独特的环境约占78%的方差，年龄占很小的比例。在两个指标有共同的environment.Conclusions非平凡的影响内的概括表示的限制，研究结果表明，一个主要的潜在作用的干预措施，旨在一个人的独特的环境，以保持良好的功能，在老化和延长活跃的生活期间。遗传效应在与年龄相关的功能障碍中起着适度但重要的作用。
Background.A key element in the quality of later life is the prevalence of age-related functional impairments. The objective of this study was to quantify the genetic and environmental influences on age-related functional impairment in a population of white male twin elders who were fit in young adulthood when entering military service. The extent of genetic influence on functioning in later life affects the role of public health, personal initiative, and service interventions.Methods.Indicators of functional impairment were determined by telephone survey and by twin pair responses to 10 indicators of basic, instrumental, and social activities, and mobility. Responses were analyzed using structural equation modeling. Prevalence and concordances were determined by zygosity status. Covariance was partitioned between twins in a pair into components attributable to additive genetics, common environment, and unique environment.Results.Data from 2721 twin pairs (1384 monozygotic and 1337 dizygotic) were analyzed for the 10 dichotomous indicators of functional impairment and for a subscale of 8 of these indicators. For the subscale, additive genes accounted for approximately 21% of covariance in liability for a higher score, whereas unique environment accounted for approximately 78% of variance, with age accounting for a very small proportion. In two indicators there were nontrivial effects of common environment.Conclusions.Within the expressed limits on generalization, the study findings suggest a major potential role for interventions aimed at a person's unique environment to maintain good functioning in aging and to lengthen the period of active life. Genetic effects play a modest but also important role in age-related functional impairment.