The relationship between habitual physical activity status and executive function in individuals with Alzheimer's disease: a longitudinal, cross-lagged panel analysis
The relationship between habitual physical activity status and executive function in individuals with Alzheimer's disease: a longitudinal, cross-lagged panel analysis
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DOI：
10.1080/13825585.2015.1080213
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发表时间：
2016-03-03
影响因子：
1.9
通讯作者：
Rusted, Jennifer
中科院分区：
文献类型：
--
作者：
Farina, Nicolas;Tabet, Naji;Rusted, Jennifer
确定习惯性体力活动状态是否对阿尔茨海默病（AD）患者1年内的执行功能变化有特异性影响。在这项纵向队列研究中，招募了45名AD参与者，并在大约1年后提供了随访数据。在基线和随访时进行执行功能测量（地图搜索任务、数字符号替换任务、受控口头单词联想任务、言语流畅性任务）和习惯性体力活动测量（老年人体力活动量表（PASE）和握力）。随后创建了单独的复合材料。还采取了其他人口统计学、生活方式和神经精神病学措施。在结构方程模型（（2）（26）=9.84，p= 0.998，比较拟合指数=1.00，近似均方根误差= 0.00）中，发现习惯性体力活动和执行功能变化之间存在显著相关（= 0.27，p= 0.04）。在交叉滞后面板分析中，发现PASE评分和高管变更之间存在显著路径（= 0.22，p= 0.01）。由于较高的习惯性体力活动水平与执行功能变化减少相关，因此可能需要在诊断为AD的个体中促进低强度的习惯性体力活动。然而，还需要进一步的研究来探索习惯性体力活动对认知领域变化轨迹的影响，以及这与这种疾病相关的潜在病理学进展的关系。
To determine whether habitual physical activity status specifically influences executive function change in Alzheimer's disease (AD) over 1 year. In this longitudinal cohort study, 45 participants with AD were recruited and provided follow-up data approximately 1 year later. Executive function measures (map search task, digit symbol substitution task, controlled oral word association task, verbal fluency task) and habitual physical activity measures (Physical Activity Scale for the Elderly (PASE) and handgrip strength) were taken at baseline and follow-up. Individual composites were subsequently created. Additional demographic, lifestyle, and neuropsychiatric measures were also taken. In a structural equation model ((2)(26)=9.84, p=.998, comparative fit index=1.00, root mean square error of approximation=.00), a significant association was found between habitual physical activity and executive function change (=.27, p=.04). In a cross-lagged panel analysis, a significant path was found between the PASE score and executive change (=.22, p=.01). As higher habitual physical activity levels were associated with reduced executive function change, the promotion of low-intensity habitual physical activities in individuals with a diagnosis of AD may be warranted. Further research is needed, however, to explore the impact of habitual physical activity on the trajectory of change across cognitive domains, and how this relates to the progression of the underlying pathology associated with this disease.