The placenta theory and the origin of infantile Hemangioma
The placenta theory and the origin of infantile Hemangioma
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DOI：
10.1089/lrb.2007.1018
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发表时间：
2007-01-01
影响因子：
1.4
通讯作者：
Folkman, Judah
中科院分区：
文献类型：
--
作者：
Barnes, Carmen M.;Christison-Lagay, Emily A.;Folkman, Judah
婴儿血管瘤的发病机制尚不清楚。近年来，许多研究的焦点都放在确定导致肿瘤发生的细胞类型(S)上。婴儿血管瘤的新发现提示前体细胞参与了该血管肿瘤的发病机制。胚胎组织和胚胎外组织都被认为是这些祖细胞的潜在来源。本文就胎盘学说作一综述，认为胎儿胎盘前体细胞是婴儿血管瘤的细胞类型。课程将特别强调胎盘血管的形成以及孕期胎盘前体细胞的存在和转运。
The pathogenesis of infantile hemangioma is unknown. In recent years, much of the focus has been placed at identifying the cell type(s) responsible for tumor initiation. New discoveries in infantile hemangioma suggest an involvement of progenitor cells in the pathogenesis of this vascular tumor. Both embryonic and extra-embryonic tissues have been postulated as potential sources for these progenitor cells. This review focuses on the placental theory, which proposes that a fetal placental progenitor is the cell type of origin for infantile hemangioma. Special emphasis will be placed on placental vasculogenesis and the presence and transit of placental progenitor cells during gestation.