Statistically Defined Parkinson's Disease Executive and Memory Cognitive Phenotypes: Demographic, Behavioral, and Structural Neuroimaging Comparisons.
Statistically Defined Parkinson's Disease Executive and Memory Cognitive Phenotypes: Demographic, Behavioral, and Structural Neuroimaging Comparisons.
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DOI：
10.3233/jpd-202166
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发表时间：
2021
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影响因子：
--
通讯作者：
Price CC
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作者：
Crowley SJ;Banan G;Amin M;Tanner JJ;Hizel L;Nguyen P;Brumback B;Rodriguez K;McFarland N;Bowers D;Ding M;Mareci TA;Price CC
一些帕金森氏病（PD）患者经历工作记忆和抑制困难，其他人学习和记忆困难，而一些人多年来只有轻微的认知缺陷。统计推导PD执行和记忆表型，并比较疾病和人口统计学变量、血管风险因素和特定神经影像学变量的PD表型与非PD同龄人的执行和记忆功能的已知相关性。非痴呆的个人与PD（n=116）和非PD同行（n=62）被招募完成神经心理学措施，抽血，结构磁共振成像。代表感兴趣的认知领域（4个执行功能，3个记忆）的测试包括在由PD参与者组成的k均值聚类分析中。将所得聚类与人口统计学和疾病相关变量、血管风险标志物、感兴趣的灰色/白色区域以及参与执行和记忆功能的已知区域之间的白色物质连通性（背外侧前额叶皮质到尾状核;内嗅皮质到脑丘）进行比较。聚类显示：1）PD执行，n=25; 2）PD记忆，n=35; 3）PD认知良好; n=56。即使在疾病变量校正后，PD Executive的皮质下灰质、白色物质和双侧背外侧-前额叶皮质至尾状核的连接也较少; PD Memory显示双侧内鼻-海马连接减少。PD认知良好组仅表现出减少壳核体积和右内嗅皮层到大脑皮层的连接相对于非PD同龄人。各组在皮质完整性测量或脑血管疾病标记物方面无统计学差异。PD认知表型表现出不同的结构性灰质和白色物质模式。我们讨论了与表型人口统计学、认知模式和脑结构特征相关的数据。
Some individuals Parkinson’s Disease (PD) experience working memory and inhibitory difficulties, others learning and memory difficulties, while some only minimal to no cognitive deficits for many years. To statistically derive PD executive and memory phenotypes, and compare PD phenotypes on disease and demographic variables, vascular risk factors, and specific neuroimaging variables with known associations to executive and memory function relative to non-PD peers. Non-demented individuals with PD (n=116) and non-PD peers (n=62) were recruited to complete neuropsychology measures, blood draw, and structural magnetic resonance imaging. Tests representing the cognitive domains of interest (4 executive function, 3 memory) were included in a k-means cluster analysis comprised of the PD participants. Resulting clusters were compared demographic and disease-related variables, vascular risk markers, gray/white regions of interest, and white matter connectivity between known regions involved in executive and memory functions (dorsolateral prefrontal cortices to caudate nuclei; entorhinal cortices to hippocampi). Clusters showed: 1) PD Executive, n=25; 2) PD Memory, n=35; 3) PD Cognitively Well; n=56. Even after disease variable corrections, PD Executive had less subcortical gray matter, white matter, and fewer bilateral dorsolateral-prefrontal cortex to caudate nucleus connections; PD Memory showed bilaterally reduced entorhinal-hippocampal connections. PD Cognitively Well group showed only reduced putamen volume and right entorhinal cortex to hippocampi connections relative to non-PD peers. Groups did not statistically differ on cortical integrity measures or cerebrovascular disease markers. PD cognitive phenotypes showed different structural gray and white matter patterns. We discuss data relative to phenotype demographics, cognitive patterns, and structural brain profiles.