Synthesis of benzimidazo[2,1-b]benzothiazole derivatives through sequential Cu-catalyzed domino coupling and Pd-catalyzed Suzuki reaction
Synthesis of benzimidazo[2,1-b]benzothiazole derivatives through sequential Cu-catalyzed domino coupling and Pd-catalyzed Suzuki reaction
复制标题
Cu催化多米诺偶联和Pd催化Suzuki反应连续合成苯并咪唑并[2,1-b]苯并噻唑衍生物
DOI：
10.1016/j.tetlet.2014.04.070
复制
发表时间：
2014-05-28
影响因子：
1.8
通讯作者：
Lv, Xin
中科院分区：
文献类型：
--
作者：
Gao, Jilong;Zhu, Jiaoyan;Lv, Xin
A variety of benzo[d]benzo[4,5]imidazo[2,1-b]thiazoles were efficiently and conveniently synthesized from the Cu-catalyzed domino coupling of o-dihaloarenes with 2-mercaptobenzimidazoles. The reaction is also applicable to a series of multi-functional substrates, affording the halo-containing products with excellent selectivity. The brominated products can further react with arylboronic acids under Pd catalysis to furnish the aryl-substituted benzimidazo[2,1-b]benzothiazole derivatives. (C) 2014 Elsevier Ltd. All rights reserved.
