A combination of roxithromycin and imipenem as an antimicrobial strategy against biofilms formed by Staphylococcus aureus.
A combination of roxithromycin and imipenem as an antimicrobial strategy against biofilms formed by Staphylococcus aureus.
复制标题
罗红霉素和亚胺培南的组合作为针对金黄色葡萄球菌形成的生物膜的抗菌策略。
DOI：
10.1093/jac/48.4.573
复制
发表时间：
2001
期刊：
影响因子：
--
通讯作者：
J. Arata
中科院分区：
文献类型：
--
作者：
O. Yamasaki;H. Akiyama;Y. Toi;J. Arata
我们研究了罗红霉素和亚胺培南联合应用对金黄色葡萄球菌生物膜模型的影响。与对照组相比，单独使用罗红霉素和亚胺培南治疗不会减少活细菌细胞的数量。然而，罗红霉素和亚胺培南联合治疗在体内模型中接种后第8天显著降低了活菌细胞数（P < 0.01）。在接种后第5天和第8天，许多多形核白细胞和巨噬细胞侵入罗红霉素和罗红霉素/亚胺培南治疗组的细菌簇，但没有侵入对照组或亚胺培南治疗组。目前的研究表明，罗红霉素和亚胺培南的组合是一个潜在的有效治疗S。金黄色葡萄球菌生物膜相关的皮肤感染，因为它可以诱导多形核白细胞侵入生物膜。
We examined the effects of a combination of roxithromycin and imipenem on a biofilm model of Staphylococcus aureus. Treatment with roxithromycin alone and imipenem alone did not decrease the number of viable bacterial cells compared with the control. However, a combination treatment of roxithromycin and imipenem significantly decreased the number of viable bacterial cells on day 8 after inoculation in the in vivo model (P < 0.01). On days 5 and 8 after inoculation, numerous polymorphonuclear leucocytes and macrophages invaded the bacterial clusters in the roxithromycin- and roxithromycin/imipenem-treated groups, but did not invade the control or imipenem-treated groups. The present study indicated that a combination of roxithromycin and imipenem is a potentially effective treatment for S. aureus biofilm-associated skin infections as it can induce the invasion of polymorphonuclear leucocytes into the biofilm.