Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory.
Cerebrovascular Damage Mediates Relations Between Aortic Stiffness and Memory.
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DOI：
10.1161/hypertensionaha.115.06398
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Mitchell GF
中科院分区：
文献类型：
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作者：
Cooper LL;Woodard T;Sigurdsson S;van Buchem MA;Torjesen AA;Inker LA;Aspelund T;Eiriksdottir G;Harris TB;Gudnason V;Launer LJ;Mitchell GF
Aortic stiffness is associated with cognitive decline. Here, we examined the association between carotid-femoral pulse wave velocity and cognitive function and investigated whether cerebrovascular remodeling and parenchymal small vessel disease damage mediate the relation. Analyses were based on 1820 (60% women) participants in the Age, Gene/Environment Susceptibility – Reykjavik Study. Multivariable linear regression models adjusted for vascular and demographic confounders showed that higher carotid-femoral pulse wave velocity was related to lower memory score (standardized β: −0.071±0.023; P=0.002). Cerebrovascular resistance and white matter hyperintensities were each associated with carotid-femoral pulse wave velocity and memory (P<0.05). Together, cerebrovascular resistance and white matter hyperintensities (total indirect effect: −0.029; 95% CI: −0.043, −0.017) attenuated the direct relation between carotid-femoral pulse wave velocity and memory (direct effect: −0.042; 95% CI: −0.087, 0.003; P=0.07) and explained approximately 41% of the observed effect. Our results suggest that in older adults, associations between aortic stiffness and memory are mediated by pathways that include cerebral microvascular remodeling and microvascular parenchymal damage.
