Indium(III) Chloride-Catalyzed Propargylation/Amination/Cycloisomerization Tandem Reaction: One-Pot Synthesis of Highly Substituted Pyrroles from Propargylic Alcohols, 1,3-Dicarbonyl Compounds and Primary Amines
Indium(III) Chloride-Catalyzed Propargylation/Amination/Cycloisomerization Tandem Reaction: One-Pot Synthesis of Highly Substituted Pyrroles from Propargylic Alcohols, 1,3-Dicarbonyl Compounds and Primary Amines
复制标题
氯化铟(III)催化的炔丙基化/胺化/环异构化串联反应：由炔丙醇、1,3-二羰基化合物和伯胺一锅法合成高度取代的吡咯
DOI：
10.1002/adsc.200800473
复制
发表时间：
2008-11-01
影响因子：
5.4
通讯作者：
Zhan, Zhuang-ping
中科院分区：
文献类型：
--
作者：
Liu, Xiao-tao;Huang, Lei;Zhan, Zhuang-ping
以炔丙醇、1，3-二羰基化合物和伯胺为原料，以氯化铟（III）为多功能催化剂，采用炔丙基化/胺化/环化异构化串联工艺合成了高取代吡咯衍生物。该方法提供了一种灵活和快速的取代吡咯路线。
A convenient one-pot propargylation/amination/cycloisomerization tandem process has been developed for the synthesis of highly substituted pyrroles derivatives from propargylic alcohols, 1,3-dicarbonyl compounds and primary amines using indium(III) chloride as a multifunctional catalyst. This method provides a flexible and rapid route to substituted pyrroles.