Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts
Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts
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DOI：
10.1016/j.envint.2015.05.008
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发表时间：
2015-09-01
影响因子：
11.8
通讯作者：
Lanki, Timo
中科院分区：
文献类型：
--
作者：
Hampel, Regina;Peters, Annette;Lanki, Timo
背景：流行病学研究表明，长期接触环境颗粒物与心血管和呼吸系统疾病死亡率增加有关。全身炎症是这种关联背后的一个合理的生物学机制。然而，目前尚不清楚PM的化学成分如何影响炎症反应。 目的：作为欧洲ESCAPE和TRANSPHORM多中心项目的一部分，研究长期接触PM的元素成分与炎症血液标志物高敏C反应蛋白（hsCRP）和纤维蛋白原之间的关联。方法：总共有 21,558 个 hsCRP 测量值和 17,428 个纤维蛋白原测量值分别来自五项和四项队列研究的横截面。住宅颗粒物长期浓度
Background: Epidemiological studies have associated long-term exposure to ambient particulate matter with increased mortality from cardiovascular and respiratory disorders. Systemic inflammation is a plausible biological mechanism behind this association. However, it is unclear how the chemical composition of PM affects inflammatory responses.Objectives: To investigate the association between long-term exposure to elemental components of PM and the inflammatory blood markers high-sensitivity C-reactive protein (hsCRP) and fibrinogen as part of the European ESCAPE and TRANSPHORM multi-center projects. Methods: In total, 21,558 hsCRP measurements and 17,428 fibrinogen measurements from cross-sections of five and four cohort studies were available, respectively. Residential long-term concentrations of particulate matter