Drug exposure in early pregnancy might be related to the effects of increased maternal progesterone in implantation period
Drug exposure in early pregnancy might be related to the effects of increased maternal progesterone in implantation period
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DOI：
10.1080/0167482x.2017.1289370
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发表时间：
2018-01-01
影响因子：
3.1
通讯作者：
Tanriverdi, H. Alper
中科院分区：
文献类型：
--
作者：
Girit, Necip;Tugrul, Ibrahim;Tanriverdi, H. Alper
目的：这个简短的沟通，旨在评估药物暴露时间和早期妊娠之间的关系，关于gestational weeks.Methods：这项研究涵盖了在3年的时间内向药理学系的致畸咨询的转介。从记录的孕妇，最后一次月经期和用药的开始日期被用来确定处方的时间与妊娠weeks.Results：在所有的三年，潜在的致畸药物处方更频繁地在第3，第4和第5孕周（在15-35天之间的怀孕）。大约75%的孕妇在这项研究中规定的药物，最常见的镇痛药，抗生素，胃肠道药物和抗抑郁药，在这些gestational weeks.Conclusions：在怀孕早期处方的时间往往符合在植入期的母体孕酮水平的增加。预后可能导致一些孕妇的疼痛感增加，焦虑，易怒和攻击性的负面情绪症状，因此导致压力增加，这反过来又可能导致个体的疼痛，感染和炎症。考虑到经常使用的药物，在此期间处方的原因可能与孕激素作用引起的症状有关。未来的研究需要更好地证明药物暴露和孕早期母体孕酮的影响之间的关系。
Aim: This short communication aims to evaluate the relation in between drug exposure time and early pregnancy regarding gestational weeks.Methods: The study covers the referrals made to the Department of Pharmacology for a teratogenic consultation in a 3-year period. From the recordings of pregnant women, the last menstrual period and the starting date of medication were used to determine the time of prescription with regard to gestational weeks.Results: In all of the three years, potentially teratogenic medication was prescribed more frequently in the 3rd, 4th and 5th gestational weeks (in between 15-35 days of pregnancy). Approximately 75% of the pregnant women in the study were prescribed with drugs, most frequently with analgesics, antibiotics, gastrointestinal drugs and antidepressants, in these gestational weeks.Conclusions: The timing of prescriptions in early pregnancy frequently coincides with the increased levels of maternal progesterone in implantation period. Progesterone may lead to negative mood symptoms of an increased pain perception, anxiety, irritability and aggression in some of the pregnant women and therefore causes an increased stress condition which in turn may result in pain, infection and inflammation in the individual. Taking the frequently used medications into consideration, the reason for prescriptions in this period might be related to the symptoms originating from the effects of progesterone. Future studies are needed to better demonstrate this association of drug exposure and effects of maternal progesterone in early pregnancy.