Effects of adrenalectomy on energy balance of obese mice are diet dependent.
Effects of adrenalectomy on energy balance of obese mice are diet dependent.
复制标题
肾上腺切除术对肥胖小鼠能量平衡的影响取决于饮食。
DOI：
10.1152/ajpregu.1985.249.1.r13
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Romsos,DR
中科院分区：
文献类型：
--
作者：
Smith,CK;Romsos,DR
肥胖（ob/ob）和瘦小鼠在3或6周龄时切除肾上腺，并饲喂高碳水化合物饲料或高脂肪半纯化饲料3周。对喂食普通饲料的肥胖小鼠进行肾上腺切除术，可降低能量摄入、能量获得和能量保留效率，使这些值与瘦小鼠的值相等。后肢肌肉增益肾上腺切除肥胖小鼠喂养的股票饮食增加了50 - 100%，血浆胰岛素浓度降低，使他们也接近精益小鼠的值。与喂食普通饲料时获得的结果相反，对喂食高脂饲料的肥胖小鼠进行肾上腺切除术仅导致能量摄入、能量获得或能量保留效率轻微降低。同样地，当切除肾上腺的肥胖小鼠喂食高脂肪饮食时，肌肉增加没有改善，血浆胰岛素浓度也没有降低。虽然肾上腺分泌物对喂养普通饲料的ob/ob小鼠的总体肥胖有很大贡献，但这些分泌物对喂养高脂饲料的ob/ob小鼠的肥胖发展是不必要的。因此，除了肾上腺分泌物本身之外，受饮食组成影响的其他因素介导了ob/ob小鼠肥胖的发展。
Obese (ob/ob) and lean mice were adrenalectomized at 3 or 6 wk of age and fed a high-carbohydrate stock diet or a high-fat semipurified diet for 3 wk. Adrenalectomy of obese mice fed the stock diet reduced the energy intake, energy gain, and efficiency of energy retention so that the values equaled those of lean mice. Hindlimb muscle gain of adrenalectomized obese mice fed the stock diet increased by 50-100%, and concentrations of plasma insulin were reduced so that they also approached values in lean mice. In contrast to results obtained when the stock diet was fed, adrenalectomy of obese mice fed the high-fat diet resulted in only slight reductions in energy intake, energy gain, or efficiency of energy retention. Likewise, muscle gain was not improved nor were plasma insulin concentrations decreased when adrenalectomized obese mice were fed the high-fat diet. Although adrenal secretions contribute substantially to the gross obesity that develops in ob/ob mice fed the stock diet, these secretions are unnecessary for development of obesity in ob/ob mice fed the high-fat diet. Factors other than adrenal secretions per se, which are influenced by diet composition, thus mediate development of obesity in ob/ob mice.