Genome archeology leading to the characterization and classification of transport proteins.
Genome archeology leading to the characterization and classification of transport proteins.
复制标题
DOI：
10.1016/s1369-5274(99)00016-8
复制
发表时间：
1999-10
影响因子：
5.4
通讯作者：
M. Saier
中科院分区：
文献类型：
--
作者：
M. Saier
在跨膜运输的研究中，分子系统发育为蛋白质结构、催化和非催化运输机制、能量耦合模式和底物特异性提供了可靠的指导。它还可以预测转运蛋白家族的进化历史，从而估计其年龄、来源和出现途径。因此，系统发育分析为转运蛋白的表征和分类提供了合理的基础。已经描述了基于功能和系统发育的通用分类系统，该系统被设计为适用于地球上活生物体中发现的所有目前已识别和尚未发现的转运蛋白。
In the study of transmembrane transport, molecular phylogeny provides a reliable guide to protein structure, catalytic and noncatalytic transport mechanisms, mode of energy coupling and substrate specificity. It also allows prediction of the evolutionary history of a transporter family, leading to estimations of its age, source, and route of appearance. Phylogenetic analyses, therefore, provide a rational basis for the characterization and classification of transporters. A universal classification system has been described, based on both function and phylogeny, which has been designed to be applicable to all currently recognized and yet-to-be discovered transport proteins found in living organisms on Earth.