Predictors of splenic function preservation in children with sickle cell anemia treated with hydroxyurea
Predictors of splenic function preservation in children with sickle cell anemia treated with hydroxyurea
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DOI：
10.1111/ejh.12361
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发表时间：
2014-11-01
影响因子：
3.1
通讯作者：
Aygun, Banu
中科院分区：
文献类型：
--
作者：
Nottage, Kerri A.;Ware, Russell E.;Aygun, Banu
研究背景90%以上的镰状细胞性贫血（SCA）患儿在2岁时丧失脾功能。脾功能可能会改善与羟基脲，但以前的研究是相互矛盾的。我们前瞻性地评估了对脾filtrative function.MethodsChildren与SCA的羟基脲研究的长期影响（HUSTLE-NCT 00305175）参加了临床评价，包括Tc（99）m肝，脾（LS）扫描前羟基脲开始和治疗后3年的最大耐受剂量（MTD）。LS扫描分类如下：无摄取，
BackgroundMore than 90% of children with sickle cell anemia (SCA) lose splenic function by the age of 2yrs. Splenic function may improve with hydroxyurea, but previous studies are conflicting. We prospectively evaluated the effect of hydroxyurea on splenic filtrative function.MethodsChildren with SCA enrolled in the Hydroxyurea Study of Long-Term Effects (HUSTLE-NCT00305175) underwent clinical evaluations including Tc(99)m liver-spleen (LS) scans before hydroxyurea initiation and after 3yrs of treatment to maximum tolerated dose (MTD). LS scans were classified as follows: no uptake,