A Predictive Structural Model of the Primate Connectome.
A Predictive Structural Model of the Primate Connectome.
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DOI：
10.1038/srep43176
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发表时间：
2017-03-03
影响因子：
4.6
通讯作者：
Hilgetag CC
中科院分区：
文献类型：
--
作者：
Beul SF;Barbas H;Hilgetag CC
解剖学上的连接性对大脑功能有很强的限制，但关于管理其组织的原则并没有普遍的共识。基于大量的定量数据，我们测试了三个因素预测灵长类动物大脑皮层连接的能力：结构相似性（结构模型），空间接近性（距离模型）和厚度相似性（厚度模型）。建筑相似性表现出最强和最一致的影响连接功能。这一参数与区域间联系的存在与否密切相关，当与空间距离相结合时，这一因素可以非常准确地预测是否存在预测。此外，架构的相似性是密切相关的层状图案的投影起源，和绝对数量的皮质连接的一个区域。相比之下，皮质厚度相似性和距离没有系统相关的连接功能。这些发现表明，皮质结构为灵长类动物大脑中的连接提供了一般的组织原则，为得到充分证实的结构模型提供了进一步的支持。
Anatomical connectivity imposes strong constraints on brain function, but there is no general agreement about principles that govern its organization. Based on extensive quantitative data, we tested the power of three factors to predict connections of the primate cerebral cortex: architectonic similarity (structural model), spatial proximity (distance model) and thickness similarity (thickness model). Architectonic similarity showed the strongest and most consistent influence on connection features. This parameter was strongly associated with the presence or absence of inter-areal connections and when integrated with spatial distance, the factor allowed predicting the existence of projections with very high accuracy. Moreover, architectonic similarity was strongly related to the laminar pattern of projection origins, and the absolute number of cortical connections of an area. By contrast, cortical thickness similarity and distance were not systematically related to connection features. These findings suggest that cortical architecture provides a general organizing principle for connections in the primate brain, providing further support for the well-corroborated structural model.