Prediction of Type II Toxin-Antitoxin Loci in Klebsiella pneumoniae Genome Sequences
Prediction of Type II Toxin-Antitoxin Loci in Klebsiella pneumoniae Genome Sequences
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DOI：
10.1007/s12539-015-0135-6
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Yiqing Wei;Dexi Bi;Dongqing Wei;Hong-Yu Ou
中科院分区：
文献类型：
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作者：
Yiqing Wei;Dexi Bi;Dongqing Wei;Hong-Yu Ou
肺炎克雷伯菌是一种日益重要的人类致病菌。这种革兰氏阴性细菌已经成为一个严重的问题，因为它的多重耐药性水平急剧增加，特别是对碳青霉烯类。毒素-抗毒素(TA)系统最近被报道参与耐药持久细胞的形成。II型TA系统由一个稳定的毒素蛋白和一个相对不稳定的能够抑制毒素的抗毒素蛋白组成。在这里，我们检查了II型TA基因座的分布，并比较了十个全序列K的TA多样性。利用生物信息学方法获得肺炎病毒基因组。在30个复制子中发现了212个可能的II型TA基因座。肺炎的症状。基于氨基酸序列相似性的分组表明，这些基因座不仅在不同的K之间分布不同。肺炎衣原体来自不同的来源，但也存在于它们的染色体和质粒之间。
Klebsiella pneumoniaeis an increasingly important bacterial pathogen to human. This Gram-negative bacterium species has become a serious concern due to its dramatic increase in the levels of multiple antibiotic resistances, particularly to carbapenems. The toxin-antitoxin (TA) system has recently been reported to be involved in the formation of drug-tolerant persister cells. The type II TA system is composed of a stable toxin protein and a relatively unstable antitoxin protein that is able to inhibit the toxin. Here, we examine the type II TA locus distribution and compare the TA diversity throughout ten completely sequencedK. pneumoniaegenomes by using bioinformatics approaches. Two hundred and twelve putative type II TA loci were identified in 30 replicons of theseK. pneumoniaestrains. The amino acid sequence similarity-based grouping shows that these loci distribute differently not only among differentK. pneumoniaestrains isolated from diverse sources, but also between their chromosomes and plasmids.