Visible-Light-Induced, Catalyst-Free Radical Cross-Coupling Cyclization of N-Allylbromodifluoroacetamides with Disulfides or Diselenides
Visible-Light-Induced, Catalyst-Free Radical Cross-Coupling Cyclization of N-Allylbromodifluoroacetamides with Disulfides or Diselenides
复制标题
N-烯丙基溴二氟乙酰胺与二硫化物或二硒化物的可见光诱导无催化剂自由基交叉偶联环化
DOI：
10.1021/acs.joc.9b03490
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发表时间：
2020
影响因子：
3.6
通讯作者：
Yang H.
中科院分区：
文献类型：
--
作者：
Ye Z.-P.;Xia P.-J.;Liu F.;Hu Y.-Z.;Song D.;Xiao J.-A.;Huang P.;Xiang H.-Y.;Chen X.-Q.;Yang H.
本文报道了一种在可见光诱导下，二硒醚或二硫醚与N-烯丙基溴二氟乙酰胺的自由基交叉偶联环化反应。该方法具有良好的官能团耐受性，并以中等至良好的产率提供了多种4-硫代和4-硒代取代的3，3-二氟-γ-内酰胺。基于对照实验，提出了一个合理的自由基-自由基交叉偶联途径。
A visible-light-induced, catalyst-free radical cross-coupling cyclization of diselenides or disulfides withN-allylbromodifluoroacetamide has been developed. This developed protocol exhibits good functional group tolerance and affords a variety of 4-thio- and 4-seleno-substituted 3,3-difluoro-γ-lactams in moderate to good yields. Based on control experiments, a plausible radical–radical cross-coupling pathway is proposed.