Hypoxia. 2. Hypoxia regulates cellular metabolism
Hypoxia. 2. Hypoxia regulates cellular metabolism
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DOI：
10.1152/ajpcell.00485.2010
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发表时间：
2011-03-01
影响因子：
5.5
通讯作者：
Chandel, Navdeep S.
中科院分区：
文献类型：
--
作者：
Wheaton, William W.;Chandel, Navdeep S.
惠顿 WW，钱德尔 NS。缺氧。 2、缺氧调节细胞代谢。 Am J Physiol Cell Physiol 300：C385-C393，2011。首次发表于 2010 年 12 月 1 日； doi:10.1152/ajpcell.00485.2010.-适应降低氧气水平（缺氧）需要协调下调代谢需求和供应，以防止 ATP 利用率和生产不匹配，从而可能最终导致生物能量崩溃。缺氧通过下调蛋白质翻译和 Na-K-ATP 酶活性来减少 ATP 利用率。缺氧会通过激活转录因子缺氧诱导因子 1 来降低电子传递链的活性，从而减少 ATP 的产生。电子传输的减少限制了缺氧期间反应氧的过量产生，并减慢了氧气消耗的速度以防止缺氧。在这篇综述中，我们讨论了这些减少适应缺氧的代谢供应和需求的机制。
Wheaton WW, Chandel NS. Hypoxia. 2. Hypoxia regulates cellular metabolism. Am J Physiol Cell Physiol 300: C385-C393, 2011. First published December 1, 2010; doi:10.1152/ajpcell.00485.2010.-Adaptation to lowering oxygen levels (hypoxia) requires coordinated downregulation of metabolic demand and supply to prevent a mismatch in ATP utilization and production that might culminate in a bioenergetic collapse. Hypoxia diminishes ATP utilization by down-regulating protein translation and the activity of the Na-K-ATPase. Hypoxia diminishes ATP production in part by lowering the activity of the electron transport chain through activation of the transcription factor hypoxia-inducible factor-1. The decrease in electron transport limits the overproduction of reactove oxygen species during hypoxia and slows the rate of oxygen depletion to prevent anoxia. In this review, we discuss these mechanisms that diminish metabolic supply and demand for adaptation to hypoxia.