A novel interventional radiology technique for arterial infusion chemotherapy against advanced pancreatic cancer.
A novel interventional radiology technique for arterial infusion chemotherapy against advanced pancreatic cancer.
复制标题
一种针对晚期胰腺癌的动脉灌注化疗的新型介入放射学技术。
DOI：
10.2214/ajr.08.1392
复制
发表时间：
2009
期刊：
影响因子：
--
通讯作者：
K. Kichikawa
中科院分区：
文献类型：
--
作者：
Toshihiro Tanaka;H. Sakaguchi;M. Sho;Kiyosei Yamamoto;H. Nishiofuku;Y. Nakajima;K. Kichikawa
目标
动脉灌注化疗治疗不可切除的胰腺癌可能是一种有吸引力的策略。我们目前正在开发一种新的介入放射学技术，以统一化疗输注的胰腺血液供应。在本文中，我们评估了该技术的可行性、治疗潜力和局限性。
材料和方法
对 28 名晚期胰腺癌患者进行回顾性分析。肠系膜上动脉栓塞后，通过统一的CT血管造影系统评估药物在肿瘤中的分布。
结果
在所有患者中，肿瘤都有来自腹腔动脉和肠系膜上动脉的双重动脉血液供应。 14 名患者（50%）成功实现了胰腺血液供应的统一。这些患者的整个胰腺肿瘤完全由腹腔动脉供血。其余14例患者，即使在栓塞后，部分肿瘤仍由肠系膜上动脉供血。在大多数失败的病例中，肿瘤已侵入小肠系膜根部或横结肠系膜。相比之下，如果侵犯胃和十二指肠，则可以实现胰腺血供的统一。栓塞后，通过腹腔动脉的动脉输注也成功地供应了整个肝脏。
结论
我们的动脉灌注化疗新技术简单、可行且耐受性良好。此外，动脉化疗对于某些患有不可切除胰腺癌的患者可能是一个突破。
OBJECTIVE
Arterial infusion chemotherapy for unresectable pancreatic cancer may be an attractive strategy. We are currently developing a new interventional radiology technique to unify the pancreatic blood supply for chemoinfusion. In this article, we evaluated the feasibility, therapeutic potential, and limitations of this technique.
MATERIALS AND METHODS
Twenty-eight patients with advanced pancreatic cancer were retrospectively reviewed. After the superior mesenteric artery was embolized, the drug distribution to the tumor was evaluated by a unified CT angiography system.
RESULTS
In all patients, tumors had dual arterial blood supplies from both the celiac and superior mesenteric arteries. Unification of pancreatic blood supply was successful in 14 patients (50%). The whole pancreatic tumor was exclusively supplied by the celiac artery in these patients. In the remaining 14 patients, a part of the tumor was still supplied by the superior mesenteric artery even after embolization. In most failed cases, the tumor had invaded to the root of the small-bowel mesentery or transverse mesocolon. By contrast, unification of the pancreatic blood supply could be achieved in cases invading to the stomach and duodenum. The whole liver was also successfully supplied by arterial infusion from the celiac artery after embolization.
CONCLUSION
Our novel technique for arterial infusion chemotherapy is simple, feasible, and well tolerated. Furthermore, arterial chemoinfusion may be a breakthrough in selected patients with unresectable pancreatic cancer.
影响因子：
6.2
作者：
Homma, H;Doi, T;Niitsu, Y
通讯作者：
Niitsu, Y