MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer.
MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer.
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DOI：
10.2147/ott.s61562
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发表时间：
2014
影响因子：
4
通讯作者：
Rodríguez-Dorantes M
中科院分区：
文献类型：
--
作者：
Salido-Guadarrama I;Romero-Cordoba S;Peralta-Zaragoza O;Hidalgo-Miranda A;Rodríguez-Dorantes M
癌细胞通讯是一个重要而复杂的过程，通过多种机制实现，使肿瘤细胞能够塑造和影响其环境。近年来，越来越多的证据表明，细胞通过释放和递送包裹在肿瘤释放（TR）外泌体中的microRNA（miRNAs）进行通信。了解来自TR外来体的miRNA的作用和作用模式在癌症生物标志物发现领域和癌症治疗的新生物医学应用的开发中至关重要。在这篇综述中，我们专注于通过TR外泌体分泌的miRNA，其通过旁分泌或内分泌方式起作用，促进癌细胞之间的多种信号传导机制。我们解决他们的贡献作为信号分子，建立，维护和增强肿瘤微环境和转移的小生境在癌症。最后，我们讨论了这些分子作为生物标志物在癌症诊断和预后中的潜在作用，以及它们作为癌症治疗中的生物医学工具的影响。
Cancer-cell communication is an important and complex process, achieved through a diversity of mechanisms that allows tumor cells to mold and influence their environment. In recent years, evidence has accumulated indicating that cells communicate via the release and delivery of microRNAs (miRNAs) packed into tumor-released (TR) exosomes. Understanding the role and mode of action of miRNAs from TR exosomes is of paramount importance in the field of cancer biomarker discovery and for the development of new biomedical applications for cancer therapeutics. In this review, we focus on miRNAs secreted via TR exosomes, which by acting in a paracrine or endocrine manner, facilitate a diversity of signaling mechanisms between cancer cells. We address their contribution as signaling molecules, to the establishment, maintenance, and enhancement of the tumor microenvironment and the metastatic niche in cancer. Finally, we address the potential role of these molecules as biomarkers in cancer diagnosis and prognosis and their impact as a biomedical tool in cancer therapeutics.