Cohort studies for characterizing measured genes.
Cohort studies for characterizing measured genes.
复制标题
用于表征测量基因的队列研究。
DOI：
10.1093/oxfordjournals.jncimonographs.a024224
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Thomas,DC
中科院分区：
文献类型：
--
作者：
Langholz,B;Rothman,N;Wacholder,S;Thomas,DC
We describe the advantages of using established cohort studies that have collected blood samples to investigate the role of genes in the etiology of cancer. These studies include the cost-efficiency and reliability of nested case-control substudies from the cohort for exploration of gene-disease associations and gene-environment interactions as well as gene penetrance. Also, the cohort may serve as a well-defined “mini-population” from which to study population stratification and molecular markers of ethnicity. We conclude that cohort studies can play a significant role in assessing the role of genetic markers for common tumors or multiple cancer sites.
