Sphingolipids in neuroinflammation.
Sphingolipids in neuroinflammation.
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DOI：
10.1007/978-3-7091-1511-4_21
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发表时间：
2013-01-01
影响因子：
--
通讯作者：
Walter, Silke
中科院分区：
文献类型：
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作者：
Davies, Laura;Fassbender, Klaus;Walter, Silke
鞘脂是细胞膜的主要成分，是细胞的“万能”，影响多种功能，包括信号转导、细胞活化、膜流动性和细胞间相互作用。在过去的几年中，鞘脂已开始在脑的主要疾病，如多发性硬化症和痴呆的病理生理学研究。调节神经炎症反应，如淋巴细胞行为，是干预导致疾病的途径的机会。在这个领域还有很多研究要做，但治疗以前无法治疗的疾病的前景迫使我们继续前进。在这里，我们回顾了鞘脂和神经炎症之间的联系目前的知识。
Sphingolipids, the main component of cellular membranes, are cellular 'jack-of-all-trades', influencing a variety of functions including signal transduction, cell activation, membrane fluidity and cell-cell interactions.In the last few years, sphingolipids have begun to be investigated in the pathophysiology of major diseases of the brain, e.g. multiple sclerosis and dementia. Modulation of neuroinflammatory responses, such as lymphocyte behaviour, is a chance to intervene in the pathways that cause disease. There is much research still to be done in this field, but the prospect of treating previously untreatable medical conditions compels us onwards. Here, we review the current knowledge of the link between sphingolipids and neuroinflammation.