D-HaploDB: a database of definitive haplotypes determined by genotyping complete hydatidiform mole samples
D-HaploDB: a database of definitive haplotypes determined by genotyping complete hydatidiform mole samples
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DOI：
10.1093/nar/gkl848
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发表时间：
2007-01-01
影响因子：
14.9
通讯作者：
Hayashi, Kenshi
中科院分区：
文献类型：
--
作者：
Higasa, Koichiro;Miyatake, Katsuyuki;Hayashi, Kenshi
最终单倍型数据库（D-HaploDB）是一个可访问的全基因组最终单倍型资源，从日本完整的包体鼹鼠（CHMs）收集中确定，每只鼹鼠都携带来自单个精子的基因组。目前，该数据库包含来自74个CHMs的281439个常见snp的基因型，这些基因型是通过高通量阵列寡核苷酸杂交技术确定的。该数据库还提供了单倍型块和连锁不平衡箱的图谱，以及可能对疾病基因关联研究有用的标签snp。本研究样本之间不太可能存在隐性亲缘关系，因为CHM的形成是一种罕见的散发性母体事件，其基因型是传入精子的基因型。这可以通过长扩展共享单体型（ESHs）的缺失得到证明。D-HaploDB可通过互联网免费访问http://orca.gen。kyushu-u.ac.jp
The Definitive Haplotype Database (D-HaploDB) is a web-accessible resource of genome-wide definitive haplotypes determined from a collection of Japanese complete hydatidiform moles (CHMs), each of which carries a genome derived from a single sperm. Currently, the database contains genotypes for 281 439 common SNPs from 74 CHMs which were determined by a high- throughput array-based oligonucleotide hybridization technique. The database also presents maps of haplotype blocks and linkage disequilibrium bins together with tagSNPs that might prove useful for association studies of disease genes. Cryptic relatedness among the samples in this study is unlikely, because the formation of a CHM is a maternal event of rare sporadic occurrence, and its genotype is that of the incoming sperm. This is demonstrated by the absence of long extended shared haplotypes (ESHs). The D-HaploDB is freely accessible via the Internet at http://orca.gen. kyushu-u.ac.jp