Postischemic administration of HMG CoA reductase inhibitor inhibits infarct expansion after transient middle cerebral artery occlusion
Postischemic administration of HMG CoA reductase inhibitor inhibits infarct expansion after transient middle cerebral artery occlusion
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DOI：
10.1016/j.brainres.2007.08.069
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发表时间：
2007-11-21
期刊：
影响因子：
2.9
通讯作者：
Kitagawa, Kazuo
中科院分区：
文献类型：
--
作者：
Sugiura, Shiro;Yagita, Yoshiki;Kitagawa, Kazuo
在局灶性脑缺血后的几天内，脑梗死扩大。抑制梗塞扩展将是缺血损伤后保护脑的有希望的策略。在这项研究中，我们研究了他汀类药物治疗的影响开始后2天短暂闭塞的大脑中动脉80分钟。治疗与普伐他汀持续输注渗透微型泵6天导致一个显着更小的梗死体积和更好的恢复运动功能，在缺血后8天相比，车辆治疗。这些结果表明，他汀类药物治疗在缺血后期间可能是有效的中风患者。(c)2007年由Elsevier B.V.出版。
Infarcts expand over a period of several days after focal cerebral ischemia. inhibition of infarct expansion would be a promising strategy for the protection of the brain after ischemic insult. In this study, we examined the effect of statin treatment initiated 2 days after transient occlusion of the middle cerebral artery for 80 min. Treatment with continuous infusion of pravastatin with an osmotic minipump for 6 days resulted in a significantly smaller infarct volume and better recovery of motor function at 8 days after ischemia compared to vehicle treatment. These results suggest that statin treatment during the postischemic period may be effective in stroke patients. (c) 2007 Published by Elsevier B.V.