Epizootiological and epidemiological study of hantavirus infection in Japan
Epizootiological and epidemiological study of hantavirus infection in Japan
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DOI：
10.1111/j.1348-0421.2004.tb03616.x
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发表时间：
2004-01-01
影响因子：
2.6
通讯作者：
Takashima, K
中科院分区：
文献类型：
--
作者：
Lokugamage, N;Kariwa, H;Takashima, K
从2000年到2003年，在日本的各个地区，包括北海道、本州、四国和九州四个主要岛屿，进行了啮齿动物汉坦病毒感染的流行病学调查。共捕获1，221只啮齿动物和食虫动物。血清阳性动物为姬鼠（A.）华美鼠（5/482，1.0%）、家鼠（R.）norvegicus（4/364，1.1%）、R. rattus（3/45，6.7%）和Clethrionomys（C.）红斑型（7/197，3.6%）。从1例血清学阳性的R.在函馆捕获的老鼠。核苷酸序列显示与首尔病毒（SEOV）原型株SR-11的同源性为96%。此外，我们还对高危人群--日本陆上自卫队在北海道的人员--进行了人类汉坦病毒感染的流行病学调查。用IFA、ELISA和WB检测207份人血标本中1份抗汉坦病毒抗体阳性。血清型特异性ELISA结果表明该个体获得了SEOV感染。本研究表明，A. speciosus，R. norvegicus、河（R. rattus和C.在日本，rufocanus携带汉坦病毒作为宿主动物。感染河rattus和R.港口地区的褐家鼠可能是人类SEOV感染的来源，并对在海港工作的旅客和个人构成威胁。
Epizootiological surveys on hantavirus infections in rodents were carried out in various areas of Japan, including the four major islands of Hokkaido, Honshu, Shikoku, and Kyushu from 2000 to 2003. A total of 1,221 rodents and insectivores were captured. Seropositive animals were found in Apodemus (A.) speciosus (5/482, 1.0%), Rattus (R.) norvegicus (4/364, 1.1%), R. rattus (3/45, 6.7%), and Clethrionomys (C.) rufocanus (7/197, 3.6%). The partial S segment was amplified from one seropositive R. rattus captured at Hakodate. The nucleotide sequence showed 96% identity with the Seoul virus (SEOV) prototype strain SR-11. In addition, we conducted an epidemiological survey on human hantavirus infection in a high-risk population, the personnel of the Japan Ground Self-defense Force on Hokkaido. One out of 207 human blood samples was positive for anti-hantavirus antibody by IFA, ELISA, and WB analysis. The result of the serotype specific ELISA indicates that this individual acquired SEOV infection. This study indicates that A. speciosus, R. norvegicus, R. rattus, and C. rufocanus carry hantaviruses as the reservoir animals in Japan. Infected R. rattus and R. norvegicus in port areas could be the sources of human SEOV infection and a threat to travelers and individuals working in seaports.