Expression of Dpp6 in mouse embryonic craniofacial development
Expression of Dpp6 in mouse embryonic craniofacial development
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Dpp6在小鼠胚胎颅面发育中的表达
DOI：
10.1016/j.acthis.2010.08.001
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发表时间：
2011-01-01
影响因子：
2.5
通讯作者：
Wang, Songlin
中科院分区：
文献类型：
--
作者：
Du, Juan;Fan, Zhipeng;Wang, Songlin
二肽基肽酶样蛋白6（DPP 6）是二肽基氨基肽酶家族的成员，在脑发育中起着独特的作用，但其在胚胎颅面发育中的表达尚不清楚。采用原位杂交和实时荧光定量PCR技术，研究Dpp 6在小鼠胚胎颅面发育过程中的表达规律。dpp 6在小鼠胚胎颅面发育过程中的表达在胚胎发育后11-13.5天（dpc）。Real-time PCR显示Dpp 6在11.5-13.5 dpc有高表达，然后随着颌面部发育的进展而降低。Dpp 6的表达模式表明Dpp 6可能参与胚胎颅面发育。(C)2010年Elsevier GmbH。All rights reserved.
Dipeptidyl-peptidase-like protein 6 (DPP6), a member of the dipeptidyl aminopeptidase family, plays distinct roles in brain development, but its expression in embryonic craniofacial development is unknown. The expression pattern of Dpp6 in the maxillofacial region during mouse embryonic craniofacial development was analyzed by whole-mount in situ hybridization on sections and by real-time PCR analysis. Dpp6 expression was detected during mouse embryonic craniofacial development in embryos 11-13.5 days post-coitum (dpc). Real-time PCR showed high Dpp6 expression present in 11.5-13.5 dpc, and this then decreased as development of maxillofacial region progressed. The expression pattern of Dpp6 suggests that Dpp6 may be involved in embryonic craniofacial development. (C) 2010 Elsevier GmbH. All rights reserved.