Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up study.
Exploratory analysis of obsessive compulsive symptom dimensions in children and adolescents: a prospective follow-up study.
复制标题
儿童和青少年强迫性症状维度的探索性分析：一项前瞻性后续研究。
DOI：
10.1186/1471-244x-6-1
复制
发表时间：
2006-01-05
期刊：
影响因子：
4.4
通讯作者：
Leboyer, Marion
中科院分区：
文献类型：
--
作者：
Delorme, Richard;Bille, Arnaud;Betancur, Catalina;Mathieu, Flavie;Chabane, Nadia;Mouren-Simeoni, Marie Christine;Leboyer, Marion
最近基于对成人患者强迫症(OC)症状的因素分析的统计方法已经确定了在基于症状的分类中似乎更有效的维度，并且随着时间的推移似乎更稳定。虽然从儿童到成年的表型连续体已经被假设，但还没有对青少年患者进行因素分析研究，也没有对儿童和青少年OC维度的稳定性进行评估。本研究旨在对强迫症(OCD)儿童和青少年的OC症状进行探索性因素分析，并调查这些因素随时间的变化过程(平均随访时间：4年)。我们第一次报告了四个症状维度，与之前在成人中描述的非常相似，强调了儿童和青少年OC症状的异质性。此外，在随访后，确定的症状维度基本上保持不变。观察到的变化与维度的强度有关，而不是从一个维度转移到另一个维度。这些发现强化了从儿童到成年的OC症状表型连续体的假设。他们还加强了使用基于维度的方法研究强迫症的临床、神经生物学和遗传异质性的兴趣。
Recent statistical approaches based on factor analysis of obsessive compulsive (OC) symptoms in adult patients have identified dimensions that seem more effective in symptom-based taxonomies and appear to be more stable over time. Although a phenotypic continuum from childhood to adulthood has been hypothesized, no factor analytic studies have been performed in juvenile patients, and the stability of OC dimensions in children and adolescents has not been assessed. This study was designed to perform an exploratory factor analysis of OC symptoms in a sample of children and adolescents with OC disorder (OCD) and to investigate the course of factors over time (mean follow-up period: four years). We report for the first time that four symptom dimensions, remarkably similar to those previously described in adults, underlined the heterogeneity of OC symptoms in children and adolescents. Moreover, after follow-up, the symptom dimensions identified remained essentially unmodified. The changes observed concerned the intensity of dimensions rather than shifts from one dimension to another. These findings reinforce the hypothesis of a phenotypic continuum of OC symptoms from childhood to adulthood. They also strengthen the interest for investigating the clinical, neurobiological and genetic heterogeneity of OCD using a dimension-based approach.