COMPARISON BETWEEN TL-201 AND TC-99M SESTAMIBI UPTAKE DURING ADENOSINE-INDUCED VASODILATION AS A FUNCTION OF CORONARY STENOSIS SEVERITY
COMPARISON BETWEEN TL-201 AND TC-99M SESTAMIBI UPTAKE DURING ADENOSINE-INDUCED VASODILATION AS A FUNCTION OF CORONARY STENOSIS SEVERITY
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DOI：
10.1161/01.cir.91.3.813
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发表时间：
1995-02-01
期刊：
影响因子：
37.8
通讯作者：
BELLER, GA
中科院分区：
文献类型：
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作者：
GLOVER, DK;RUIZ, M;BELLER, GA
背景：已知心肌摄取Tl-201或Tc-99m sestamibi （sestamibi）在高冠状动脉血流速率时达到平稳。然而，这两种示踪剂之间很少有直接比较，以确定两种示踪剂摄取平台的差异对不同严重程度的冠状动脉狭窄的检测有何影响。方法和结果在22只狗的左前降支（LAD）和旋支（LCx）动脉上安装血流传感器。在6只非狭窄犬中，腺苷直接输注到LAD中，而16只患有严重（n=7）或轻度（n=9） LAD狭窄的犬则接受静脉输注。在峰值流速下，同时注射Tl-201 （0.5 mCi）、sestamibi （5 - 8 mCi）和放射性标记微球。5分钟后处死狗，进行心脏切片离体成像和多个心肌样本的伽马井计数。Tl-201和sestamibi吸收量均未与流量成正比增加。在6只无症状犬中，LAD流量增加5倍，分别使Tl-201和sestamibi摄取增加202+/-6%和138+/-4% (P
Background Myocardial uptake of either Tl-201 or Tc-99m sestamibi (sestamibi) is known to plateau at high coronary flow rates. However, few direct comparisons have been made between these tracers to determine what effect differences in the uptake plateau for the two tracers may have on the detection of coronary stenoses of various severities.Methods and Results Twenty-two dogs were instrumented with flow transducers on the left anterior descending (LAD) and circumflex (LCx) arteries. In 6 nonstenotic dogs, adenosine was infused directly into the LAD, whereas 16 dogs with either critical (n=7) or mild (n=9) LAD stenoses received an intravenous infusion. At peak flow, Tl-201 (0.5 mCi), sestamibi (5 to 8 mCi), and radiolabeled microspheres were injected simultaneously. Five minutes later, dogs were killed, and ex vivo imaging of heart slices and gamma-well counting of multiple myocardial samples was performed. Neither Tl-201 nor sestamibi uptake increased in direct proportion to flow. In the 6 nonste notic dogs, a fivefold increase in LAD flow increased Tl-201 and sestamibi uptake by only 202+/-6% and 138+/-4%, respectively (P