Lack of protracted behavioral abnormalities following intermittent or continuous chronic mild hypoxia in perinatal C57BL/6 mice
Lack of protracted behavioral abnormalities following intermittent or continuous chronic mild hypoxia in perinatal C57BL/6 mice
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DOI：
10.1016/j.neulet.2014.06.022
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发表时间：
2014-08-08
影响因子：
2.5
通讯作者：
Inta, Dragos
中科院分区：
文献类型：
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作者：
Lima-Ojeda, Juan M.;Vogt, Miriam A.;Inta, Dragos
一些前瞻性研究表明，围产期缺氧是精神疾病如精神分裂症的危险因素。据认为，出生前或出生期间的缺氧可能会导致改变，导致在成年早期的长期临床表现。然而，只有一小部分有围产期缺氧史的儿童后来出现精神病症状，因此尚不清楚缺氧是否足以引发长期的行为变化。在此，我们将出生后第3-7天（P3-P7）的C57 BL/6小鼠暴露于两种建立的慢性轻度缺氧（10%环境O2）的模式，间歇和连续。随后，使用几种基本的行为测试分析了年轻成年阶段的小鼠。先前的研究表明，在这些范例中，皮质损伤严重，但只是短暂的;目前尚不清楚，如果这些可逆的形态学变化伴随着长期的行为影响。我们发现，无论是间歇性或连续性围产期缺氧诱导长期的行为改变。这可能是由于围产期大脑的高再生能力。其他可能性包括对此处使用的小鼠品系的围产期缺氧的潜在抗性，或者缺氧水平不足以引发显著的行为变化。因此，我们的数据不排除围产期缺氧作为精神疾病的危险因素的作用。相反，他们认为，其他更严重的缺氧条件（如缺氧）或其他因素（如遗传风险因素）的存在是产生长期行为异常所必需的。(C)2014爱思唯尔爱尔兰有限公司版权所有。
Several prospective studies indicated perinatal hypoxia as risk factor for psychiatric disorders like schizophrenia. It is thought that hypoxia prior to or during birth may contribute to alterations leading to the protracted clinical manifestation during young adulthood. However, only a small fraction of children with a history of perinatal hypoxia develop later psychotic symptoms, therefore it is not known if hypoxia alone is sufficient to trigger long-term behavioral changes. Here we exposed C57BL/6 mice from postnatal day 3-7 (P3-P7) to two established paradigms of chronic mild hypoxia (10% ambient 02), intermittent and continuous. Subsequently, mice were analysed during young adult stages using several basic behavioral tests. Previous studies demonstrated severe, but only transient, cortical damage in these paradigms; it is not clear, if these reversible morphological changes are accompanied by long-term behavioral effects. We found that neither intermittent nor continuous perinatal hypoxia induced long-term behavioral alterations. This may be due to the high regenerative capacity of the perinatal brain. Other possibilities include a potential resistance to perinatal hypoxia of the mouse strain used here or a level of hypoxia that was insufficient to trigger significant behavioral changes. Therefore, our data do not exclude a role of perinatal hypoxia as risk factor for psychiatric disorders. They rather suggest that either other, more severe hypoxic conditions like anoxia, or the presence of additional factors (as genetic risk factors) are necessary for generating long-term behavioral abnormalities. (C) 2014 Elsevier Ireland Ltd. All rights reserved.