Cortisol reactivity and situational drug use in cocaine-dependent females.
Cortisol reactivity and situational drug use in cocaine-dependent females.
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可卡因依赖女性的皮质醇反应性和情境药物使用。
DOI：
10.1016/j.psychres.2019.112611
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发表时间：
2019
影响因子：
11.3
通讯作者：
Sherman,Brian
中科院分区：
文献类型：
--
作者：
Campbell,Lauren;Galuska,Chad;McRae-Clark,Aimee;Sherman,Brian
在这项双盲研究中，可卡因依赖妇女在两次线索反应程序之前给予药物应激源或安慰剂。吸毒情况调查表是一种自我报告问卷，测量复发的前因，由三个子量表组成：消极的、积极的和诱惑的情景吸毒。研究假设，与安慰剂相比，IDTS得分较高的女性在接受育亨宾治疗时，对提示反应任务的皮质醇反应更强。所有三个子量表在育亨宾注射后的相同时间和线索暴露后的即刻都显示出显著意义。我们的结果可能表明，在这一人群中，情境和生理风险因素之间存在关联。
In this double-blind study, cocaine-dependent women were administered a pharmacological stressor or placebo prior to two cue-reactivity procedures. The Inventory of Drug Taking Situations is a self-report questionnaire measuring antecedents to relapse and is comprised of three subscales: negative, positive, and temptation situational drug use. It was hypothesized that women with higher IDTS scores would have a greater cortisol response to the cue-reactivity task while receiving yohimbine versus placebo. All three subscales showed significance during the same times after yohimbine administration and immediately post-cue exposure. Our results may suggest an association between situational and physiological risk factors in this population.