Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans
Increased expression of TGF-beta 1 in brain tissue after ischemic stroke in humans
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DOI：
10.1161/01.str.27.5.852
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发表时间：
1996-05-01
期刊：
影响因子：
8.3
通讯作者：
Kaluza, J
中科院分区：
文献类型：
--
作者：
Krupinski, J;Kumar, P;Kaluza, J
背景与目的脑血管闭塞导致缺血性脑卒中，随后微血管增生，即血管生成。这一过程在被称为缺血半暗带的梗死区特别明显。血管形成的增加可能是由血管生成因子的作用引起的，如tgf - β 1，它是血管生成的强大调节剂。方法在本研究中，我们检测了10例缺血性脑卒中患者脑样本中编码tgf - β 1的mRNA的表达。结果缺血半暗区tgf - β 1 mRNA表达水平最高，而对侧正常半暗区tgf - β 1 mRNA表达水平最低
Background and Purpose Occlusion in cerebral vessels resuits in ischemic stroke and is followed by proliferation of microvessels, ie, angiogenesis. The process is particularly marked in the bolder zone of the infarct, known as the ischemic penumbra. This increase in vascularization is likely to be caused by the action of angiogenic factors, such as TGF-beta 1, which is a powerful regulator of angiogenesis.Methods In this study we examined 10 brain samples from patients who suffered from ischemic stroke for the expression of mRNA encoding TGF-beta 1.Results The ischemic penumbra contained the highest levels of TGF-beta 1 mRNA, whereas the normal contralateral hemispheres had the least (P