Antibiotic therapy for preterm premature rupture of membranes - results of a multicenter study
Antibiotic therapy for preterm premature rupture of membranes - results of a multicenter study
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DOI：
10.1515/jpm.2006.035
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发表时间：
2006-05-01
影响因子：
2.4
通讯作者：
Hopp, H
中科院分区：
文献类型：
--
作者：
Fuhr, NA;Becker, C;Hopp, H
目的：目的探讨美洛西林钠在早产胎膜早破（preterm premature rupture of membranes，pPROM）中的初步应用是否能减少妊娠和降低新生儿发病率。在这项前瞻性、随机、双盲、一项安慰剂对照的多中心研究，共检查了105名妊娠24 + 0和32 + 6周的pPROM孕妇，这些孕妇接受皮质激素和宫缩抑制剂以及美洛西林的静脉注射（3 x 2 g/d）或安慰剂。结果：美洛西林组延长妊娠7 d以上的发生率为63.8%，安慰剂组为44.8%（P < 0.05）;使用抗生素治疗的母亲的婴儿新生儿感染、RDS、IVH和NEC较少。总发病率显着降低verum组（P = 0.02）。结论：抗生素管理早产胎膜早破与妊娠期延长和新生儿感染性发病率降低。
Aims: To evaluate whether primary application of mezlozillin in preterm premature rupture of membranes (pPROM) prolongs pregnancy and lowers neonatal morbidity.Methods: In this prospective, randomized, double blind, placebo-controlled multicenter study a total of 105 pregnant women with pPROM between 24 + 0 and 32 + 6 weeks of gestation were examined receiving i.v. injections of corticoids and tocolytics as well as mezlocillin (3 x 2 g/d) or placebo. Assessed factors were prolongation of pregnancy and neonatal morbidity such as neonatal infection, respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH) and necrotizing enterocolitis (NEC).Results: Prolongation of pregnancy by more than 7 days was achieved in 63.8% of the mezlocillin group versus 44.8% of the placebo group (P < 0.05). The babies of mothers treated with anibiotics had fewer neonatal infections, RDS, IVH and NEC. Total morbidity was significantly lowered in the verum group (P = 0.02).Conclusions: Antibiotic administration following preterm premature rupture of membranes is associated with a prolongation of pregnancy and a reduction of neonatal infectious morbidity.