Posterior Medial Frontal Cortex Activity Predicts Post-Error Adaptations in Task-Related Visual and Motor Areas
Posterior Medial Frontal Cortex Activity Predicts Post-Error Adaptations in Task-Related Visual and Motor Areas
复制标题
DOI：
10.1523/jneurosci.4299-10.2011
复制
发表时间：
2011-02-02
影响因子：
5.3
通讯作者：
Ullsperger, Markus
中科院分区：
文献类型：
--
作者：
Danielmeier, Claudia;Eichele, Tom;Ullsperger, Markus
正如小塞涅卡所说，“犯错是人之常情，但坚持是恶魔。“为了防止错误的重复，人类表现监测往往会触发适应，如一般放缓和/或注意力集中。后内侧额叶皮层（pMFC）被认为是监测性能问题，并与其他大脑区域，实现必要的适应。而以前的研究表明，pMFC和侧前额叶区域之间的相互作用，在这里，我们证明，在发生错误的pMFC选择性地与知觉和运动区域的相互作用，从而驱动注意力集中到任务相关的信息，并诱导运动适应观察错误后放缓。干扰任务的功能性磁共振成像数据显示，错误相关的pMFC活动预测了以下情况：（1）编码任务相关刺激特征的感知区域中随后的活动增强;（2）编码分心刺激特征的感知区域中的活动抑制;以及（3）运动系统中错误后减慢相关活动减少。此外，弥散加权成像显示了与运动抑制系统（包括右额下回和丘脑底核）相连的pMFC区域下方的个体错误后减慢和白色物质完整性的相关性。因此，任务表现的干扰通过pMFC与前额叶皮层以外的多个任务相关脑区的功能相互作用来补救，这导致在感知和运动水平上的广泛的适应性过程。
As Seneca the Younger put it, "To err is human, but to persist is diabolical." To prevent repetition of errors, human performance monitoring often triggers adaptations such as general slowing and/or attentional focusing. The posterior medial frontal cortex (pMFC) is assumed to monitor performance problems and to interact with other brain areas that implement the necessary adaptations. Whereas previous research showed interactions between pMFC and lateral-prefrontal regions, here we demonstrate that upon the occurrence of errors the pMFC selectively interacts with perceptual and motor regions and thereby drives attentional focusing toward task-relevant information and induces motor adaptation observed as post-error slowing. Functional magnetic resonance imaging data from an interference task reveal that error-related pMFC activity predicts the following: (1) subsequent activity enhancement in perceptual areas encoding task-relevant stimulus features; (2) activity suppression in perceptual areas encoding distracting stimulus features; and (3) post-error slowing-related activity decrease in the motor system. Additionally, diffusion-weighted imaging revealed a correlation of individual post-error slowing and white matter integrity beneath pMFC regions that are connected to the motor inhibition system, encompassing right inferior frontal gyrus and subthalamic nucleus. Thus, disturbances in task performance are remedied by functional interactions of the pMFC with multiple task-related brain regions beyond prefrontal cortex that result in a broad repertoire of adaptive processes at perceptual as well as motor levels.