Translatability of Scalp EEG Recordings of Duration-Deviant Mismatch Negativity Between Macaques and Humans: A Pilot Study
Translatability of Scalp EEG Recordings of Duration-Deviant Mismatch Negativity Between Macaques and Humans: A Pilot Study
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DOI：
10.3389/fpsyt.2020.00874
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发表时间：
2020-08-26
影响因子：
4.7
通讯作者：
Uka, Takanori
中科院分区：
文献类型：
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作者：
Tada, Mariko;Suda, Yuki;Uka, Takanori
失配负性（MMN）是由重复出现的声音突然变化引起的听觉事件相关电位（ERP）的负偏转。在精神分裂症患者中，MMN持续减少，这使其成为一种有希望的生物标志物。基于头皮脑电图（EEG）记录的非人类灵长类动物（NHP） MMN模型可以提供一个有用的翻译工具，因为非人类灵长类动物（如猕猴）和人类之间的前额叶和听觉皮层具有高度的结构同源性。然而，在之前的MMN研究中，由于任务设置的差异，使用的NHP模型不允许与人类进行比较。此外，精神分裂症患者的持续偏差MMN （dMMN）的减少幅度大于频率偏差MMN (fMMN)，但从未在NHP模型中得到证实。在这项研究中，我们确定在猕猴头皮脑电图记录中是否可以观察到dMMN。用两只日本猕猴的额叶电极（Fz）记录脑电图。与临床设置一致，听觉刺激由两种纯音组成，一种标准音调和一种异常音调，在一个奇怪的范式中。偏差音和标准音的持续时间不同（标准音和偏差音的持续时间分别为50 ms和100 ms）。在两只猴子身上观察到的dMMN的潜伏期约为200毫秒，与人类的潜伏期相当。与fMMN的比较表明，dMMN的延迟时间较长。通过弥合基础研究和临床研究之间的差距，我们的结果将有助于精神分裂症创新治疗策略的发展。
Mismatch negativity (MMN) is a negative deflection of the auditory event-related potential (ERP) elicited by an abrupt change in a sound presented repeatedly. In patients with schizophrenia, MMN is consistently reduced, which makes it a promising biomarker. A non-human primate (NHP) model of MMN based on scalp electroencephalogram (EEG) recordings can provide a useful translational tool, given the high structural homology of the prefrontal and auditory cortices between NHPs, such as macaques, and humans. However, in previous MMN studies, the NHP models used did not allow for comparison with humans because of differences in task settings. Moreover, duration-deviant MMN (dMMN), whose reduction is larger than that in the frequency-deviant MMN (fMMN) in patients with schizophrenia, has never been demonstrated in NHP models. In this study, we determined whether dMMN can be observed in macaque scalp EEG recordings. EEGs were recorded from frontal electrodes (Fz) in two Japanese macaques. Consistent with clinical settings, auditory stimuli consisted of two pure tones, a standard and a deviant tone, in an oddball paradigm. The deviant and standard tones differed in duration (50 and 100 ms for the standard and deviant tones, respectively). A robust dMMN with a latency of around 200 ms, comparable to that in humans, was observed in both monkeys. A comparison with fMMN showed that the dMMN latency was the longer of the two. By bridging the gap between basic and clinical research, our results will contribute to the development of innovative therapeutic strategies for schizophrenia.