Continuous vagus nerve stimulation effects on the gut-brain axis in swine
Continuous vagus nerve stimulation effects on the gut-brain axis in swine
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DOI：
10.1111/j.1525-1403.2007.00087.x
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发表时间：
2007-01-01
期刊：
影响因子：
2.8
通讯作者：
Uson, Jesus
中科院分区：
文献类型：
--
作者：
Diaz-Gueemes, Idoia;Sanchez, Francisco M.;Uson, Jesus
目标。本研究旨在评估迷走神经刺激对猪食物摄入模式的影响并确定电刺激方向。材料和方法。将十五头大白猪随机分为三组，A-C 组。所有动物均在胃食管交界处植入迷走神经刺激器。 A 组关闭刺激，B 组和 C 组开启刺激。A 组和 B 组记录食物摄入量和体重，C 组则不记录，用于测量迷走神经刺激方向以及对心率和血压的影响。 C 组测量的变量包括脑电双频指数、血压和心率。使用学生 t 检验和单向方差分析来检测组之间的差异。处死所有动物以鉴定植入和刺激对迷走神经的影响。结果。在食物摄入量方面，A组和B组之间没有差异；然而，体重确实持续增加。在刺激过程中，C组的动脉压显着下降，而心率和脑电双频指数则增加。结论。本研究中应用的刺激方案不足以引起猪采食行为的变化；然而，它确实增加了中枢神经系统的活动。
Objectives. This study was designed to assess vagus nerve stimulation effects on the food intake pattern in swine and determine the electrical stimulus direction. Material and Methods. Fifteen Large White pigs were randomly divided into three groups, groups A-C. All animals underwent implantation of a vagus nerve stimulator at the gastro-esophogeal junction. In group A, the stimulation was switched off, whereas stimulation was switched on in groups B and C. Food intake and body weight were registered in groups A and B, but not in group C, which was used to measure direction of stimulation in the vagus and effect on heart rate and blood pressure. Variables measured in group C included the bispectral index, blood pressure, and heart rate. A Student's t-test and one-way analysis of variance were used to detect differences between groups. All animals were sacrificed to identify effects of implantation and stimulation on the vagus nerve. Results. With respect to food intake, there was no difference between groups A and B; however, body weight did register a continuous increase. During stimulation, in group C arterial pressures decreased significantly, whereas the heart rate and bispectral index increased. Conclusion. The stimulation protocol applied in this study was insufficient to cause changes in the feeding behavior of swine; however, it did increase central nervous system activity.