Biochemical control systems for small molecule damage in plants
Biochemical control systems for small molecule damage in plants
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DOI：
10.1080/15592324.2018.1477906
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发表时间：
2018-01-01
影响因子：
2.9
通讯作者：
Maurino, V. G.
中科院分区：
文献类型：
--
作者：
Huedig, M.;Schmitz, J.;Maurino, V. G.
作为一个系统，植物代谢远非完美：小分子（代谢物、辅因子、辅酶和无机分子）经常被不需要的酶或自发反应破坏。在这里，我们讨论了小分子损伤生物学的新兴原理。我们认为植物进化出至少三种不同的系统来控制小分子损伤：(i)修复，将受损分子恢复到原始状态；（ii）清除，将活性分子转化为无害产物；（三）转向，在此过程中，可能形成的受损分子被抑制。我们通过描述这三类中的每一类的具体例子来说明植物小分子损伤控制的概念。我们强调了我们期望未来研究将为这些系统提供的有趣见解，并讨论了在植物中发现新的小分子损伤控制系统的有前途的策略。
As a system, plant metabolism is far from perfect: small molecules (metabolites, cofactors, coenzymes, and inorganic molecules) are frequently damaged by unwanted enzymatic or spontaneous reactions. Here, we discuss the emerging principles in small molecule damage biology. We propose that plants evolved at least three distinct systems to control small molecule damage: (i) repair, which returns a damaged molecule to its original state; (ii) scavenging, which converts reactive molecules to harmless products; and (iii) steering, in which the possible formation of a damaged molecule is suppressed. We illustrate the concept of small molecule damage control in plants by describing specific examples for each of these three categories. We highlight interesting insights that we expect future research will provide on those systems, and we discuss promising strategies to discover new small molecule damage-control systems in plants.